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    Pih1d2 PIH1 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pih1d2provided by RGD
    Official Full Name
    PIH1 domain containing 2provided by RGD
    Primary source
    RGD:1310503
    See related
    EnsemblRapid:ENSRNOG00000009965 AllianceGenome:RGD:1310503
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310503
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in box C/D snoRNP assembly and rRNA processing. Predicted to be part of R2TP complex; protein folding chaperone complex; and ribonucleoprotein complex. Predicted to be active in cytoplasm. Orthologous to human PIH1D2 (PIH1 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 67.4), Heart (RPKM 64.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pih1d2 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (59863271..59871465)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (50966885..50976901)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55050284..55060289)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene translocase of inner mitochondrial membrane 8 homolog B Neighboring gene NKAP domain containing 1 Neighboring gene dihydrolipoamide S-acetyltransferase Neighboring gene DIX domain containing 1 Neighboring gene uncharacterized LOC120094337

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. Simicek M, et al. Nat Cell Biol, 2013 Oct. PMID 24056301
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of R2TP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PIH1 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191793.1 → NP_001178722.1  PIH1 domain-containing protein 2

      See identical proteins and their annotated locations for NP_001178722.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZRH4
      Related
      ENSRNOP00000013240.4, ENSRNOT00000013242.7
      Conserved Domains (1) summary
      cl00175
      Location:25 → 313
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      59863271..59871465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081448.2 → XP_038937376.1  PIH1 domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      pfam18201
      Location:147 → 214
      PIH1_CS; PIH1 CS-like domain
      cl00175
      Location:4 → 69
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    2. XM_006243029.5 → XP_006243091.1  PIH1 domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006243091.1

      UniProtKB/TrEMBL
      D3ZRH4
      Conserved Domains (1) summary
      cl00175
      Location:25 → 313
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    3. XM_063265445.1 → XP_063121515.1  PIH1 domain-containing protein 2 isoform X2

    4. XM_063265447.1 → XP_063121517.1  PIH1 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6J4E5

    5. XM_006243030.5 → XP_006243092.1  PIH1 domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006243092.1

      UniProtKB/TrEMBL
      D3ZRH4
      Conserved Domains (1) summary
      cl00175
      Location:25 → 313
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    6. XM_006243028.5 → XP_006243090.1  PIH1 domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006243090.1

      UniProtKB/TrEMBL
      D3ZRH4
      Conserved Domains (1) summary
      cl00175
      Location:25 → 313
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    7. XM_063265448.1 → XP_063121518.1  PIH1 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6J4E5

    8. XM_063265446.1 → XP_063121516.1  PIH1 domain-containing protein 2 isoform X2

    9. XM_039081449.2 → XP_038937377.1  PIH1 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6J4E5
      Conserved Domains (1) summary
      pfam18201
      Location:116 → 183
      PIH1_CS; PIH1 CS-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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