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    Gsta5 glutathione S-transferase alpha 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gsta5provided by RGD
    Official Full Name
    glutathione S-transferase alpha 5provided by RGD
    Primary source
    RGD:1593189
    See related
    EnsemblRapid:ENSRNOG00000029861 AllianceGenome:RGD:1593189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gsta2
    Summary
    Enables glutathione binding activity and glutathione transferase activity. Involved in xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 6559.5), Kidney (RPKM 3991.1) and 1 other tissue See more
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    Genomic context

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    See Gsta5 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87985768..87997766)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (79105561..79117472)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85553659..85564914)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12, pseudogene 1 Neighboring gene glutathione S-transferase alpha 4 Neighboring gene U6 spliceosomal RNA Neighboring gene glutathione S-transferase alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino acid sequence of the rat glutathione transferase Ya subunit. Taylor JB, et al. Biochem J, 1984 Apr 1. PMID 6547043, Free PMC Article
    2. Cloning and sequence analysis of a cDNA plasmid for one of the rat liver glutathione S-transferase subunits. Tu CP, et al. Nucleic Acids Res, 1982 Sep 25. PMID 6292839, Free PMC Article
    3. Expression and sequence analysis of rat liver glutathione S-transferase genes. Pickett CB, et al. Adv Exp Med Biol, 1986. PMID 3766257
    4. Structural analysis of a rat liver glutathione S-transferase Ya gene. Telakowski-Hopkins CA, et al. Proc Natl Acad Sci U S A, 1986 Dec. PMID 3025841, Free PMC Article
    5. Expression of a cDNA encoding a rat liver glutathione S-transferase Ya subunit in Escherichia coli. Wang RW, et al. Arch Biochem Biophys, 1989 Mar. PMID 2645828

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114217

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to stilbenoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase alpha-2
    Names
    GHS transferase
    GST 1b-1b
    GST A2-2
    GST Ya2
    glutathione S-transferase Ya subunit
    glutathione S-transferase Ya-2
    glutathione transferase YA subunit
    NP_001010921.1
    XP_017451300.1
    XP_017451301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010921.2 → NP_001010921.1  glutathione S-transferase alpha-2

      See identical proteins and their annotated locations for NP_001010921.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P04903, Q63715
      UniProtKB/TrEMBL
      A0A096MIU0, Q4FZZ3
      Related
      ENSRNOP00000043510.5, ENSRNOT00000044944.7
      Conserved Domains (3) summary
      PTZ00057
      Location:1 → 208
      PTZ00057; glutathione s-transferase; Provisional
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      87985768..87997766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595811.3 → XP_017451300.1  glutathione S-transferase alpha-2 isoform X1

      UniProtKB/Swiss-Prot
      P04903, Q63715
      UniProtKB/TrEMBL
      A0A096MIU0, Q4FZZ3
      Related
      ENSRNOP00000091487.2, ENSRNOT00000106378.2
      Conserved Domains (3) summary
      PTZ00057
      Location:1 → 208
      PTZ00057; glutathione s-transferase; Provisional
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. XM_017595812.3 → XP_017451301.1  glutathione S-transferase alpha-2 isoform X1

      UniProtKB/Swiss-Prot
      P04903, Q63715
      UniProtKB/TrEMBL
      A0A096MIU0, Q4FZZ3
      Conserved Domains (3) summary
      PTZ00057
      Location:1 → 208
      PTZ00057; glutathione s-transferase; Provisional
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04903.2 GenPept UniProtKB/Swiss-Prot:P04903

    Gene LinkOut

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