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    Gls glutaminase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24398, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glsprovided by RGD
    Official Full Name
    glutaminaseprovided by RGD
    Primary source
    RGD:2707
    See related
    EnsemblRapid:ENSRNOG00000056246 AllianceGenome:RGD:2707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glut; RATGLUT
    Summary
    Predicted to enable glutaminase activity and identical protein binding activity. Predicted to be involved in glutamine family amino acid metabolic process; intracellular glutamate homeostasis; and protein homotetramerization. Predicted to act upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 405.8), Brain (RPKM 295.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gls in Genome Data Viewer
    Location:
    9q22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (56836584..56908861)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (49344616..49416900)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (54212622..54284879)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene signal transducer and activator of transcription 1 Neighboring gene signal transducer and activator of transcription 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glutaminase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutamate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glutamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glutamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glutamine catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular glutamate homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular glutamate homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of respiratory gaseous exchange by nervous system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in suckling behavior IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within suckling behavior ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutaminase kidney isoform, mitochondrial
    Names
    K-glutaminase
    L-glutamine amidohydrolase
    kidney-type glutaminase
    NP_001103438.2
    NP_036701.3
    XP_008765297.1
    XP_038938932.1
    XP_038938933.1
    XP_038938934.1
    XP_038938935.1
    XP_038938937.1
    XP_038938938.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109968.3NP_001103438.2  glutaminase kidney isoform, mitochondrial isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P13264, Q8R421
      UniProtKB/TrEMBL
      A0A0G2KAN7
      Related
      ENSRNOP00000075466.1, ENSRNOT00000078073.3
      Conserved Domains (2) summary
      pfam04960
      Location:248532
      Glutaminase
      pfam17959
      Location:143226
      EF-hand_14; EF-hand domain
    2. NM_012569.4NP_036701.3  glutaminase kidney isoform, mitochondrial isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P13264, Q8R421
      UniProtKB/TrEMBL
      A0A0G2K1T0
      Related
      ENSRNOP00000071972.1, ENSRNOT00000090026.3
      Conserved Domains (4) summary
      sd00045
      Location:561587
      ANK; ANK repeat [structural motif]
      pfam17959
      Location:143226
      EF-hand_14; EF-hand domain
      pfam04960
      Location:248532
      Glutaminase
      pfam12796
      Location:561653
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      56836584..56908861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767075.4XP_008765297.1  glutaminase kidney isoform, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P13264, Q8R421
      Conserved Domains (1) summary
      pfam04960
      Location:248534
      Glutaminase; Glutaminase
    2. XM_039083005.2XP_038938933.1  glutaminase kidney isoform, mitochondrial isoform X3

      Conserved Domains (2) summary
      pfam17959
      Location:143226
      EF-hand_14; EF-hand domain
      cl00907
      Location:248421
      Glutaminase
    3. XM_039083006.2XP_038938934.1  glutaminase kidney isoform, mitochondrial isoform X4

      Conserved Domains (2) summary
      pfam17959
      Location:143226
      EF-hand_14; EF-hand domain
      cl00907
      Location:248350
      Glutaminase
    4. XM_039083007.2XP_038938935.1  glutaminase kidney isoform, mitochondrial isoform X5

      Conserved Domains (2) summary
      pfam17959
      Location:143226
      EF-hand_14; EF-hand domain
      cl00907
      Location:248352
      Glutaminase
    5. XM_039083004.2XP_038938932.1  glutaminase kidney isoform, mitochondrial isoform X2

      Conserved Domains (3) summary
      sd00045
      Location:333359
      ANK; ANK repeat [structural motif]
      pfam04960
      Location:20304
      Glutaminase
      pfam12796
      Location:333425
      Ank_2; Ankyrin repeats (3 copies)
    6. XM_039083010.2XP_038938938.1  glutaminase kidney isoform, mitochondrial isoform X6

      Conserved Domains (3) summary
      sd00045
      Location:224250
      ANK; ANK repeat [structural motif]
      pfam04960
      Location:13195
      Glutaminase
      pfam12796
      Location:224316
      Ank_2; Ankyrin repeats (3 copies)
    7. XM_039083009.2XP_038938937.1  glutaminase kidney isoform, mitochondrial isoform X6

      Conserved Domains (3) summary
      sd00045
      Location:224250
      ANK; ANK repeat [structural motif]
      pfam04960
      Location:13195
      Glutaminase
      pfam12796
      Location:224316
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_010054565.1 RNA Sequence

    2. XR_010054566.1 RNA Sequence

    3. XR_010054568.1 RNA Sequence

    4. XR_010054567.1 RNA Sequence