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    Abi2 abl-interactor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286928, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Abi2provided by RGD
    Official Full Name
    abl-interactor 2provided by RGD
    Primary source
    RGD:628771
    See related
    EnsemblRapid:ENSRNOG00000017707 AllianceGenome:RGD:628771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; lens fiber cell morphogenesis; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within several processes, including generation of neurons; learning or memory; and peptidyl-tyrosine phosphorylation. Predicted to be located in several cellular components, including actin filament; filopodium tip; and lamellipodium. Predicted to be part of SCAR complex. Predicted to be active in several cellular components, including adherens junction; glutamatergic synapse; and postsynaptic actin cytoskeleton. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 483.5), Heart (RPKM 145.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abi2 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69321072..69490630)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61827186..61905703)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67234612..67284504)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 2, pseudogene 1 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene uncharacterized LOC102547711 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a complementary DNA for a thyroid hormone-responsive protein in mature rat cerebral tissue. Shah GN, et al. Biochem J, 1997 Oct 15. PMID 9359437, Free PMC Article
    2. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Dai Z, et al. Genes Dev, 1995 Nov 1. PMID 7590236
    3. Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2. Kano S, et al. Cancer Res, 2008 Jul 15. PMID 18632609
    4. The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. Stradal T, et al. Curr Biol, 2001 Jun 5. PMID 11516653
    5. ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Grove M, et al. Mol Cell Biol, 2004 Dec. PMID 15572692, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within learning or memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lens fiber cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zonula adherens assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    abl interactor 2
    Names
    rCG22366-like
    thyroid hormone responsive protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393698.1 → NP_001380627.1  abl interactor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6IPC7, F1LYA6
      Related
      ENSRNOP00000078426.2, ENSRNOT00000113763.2
      Conserved Domains (2) summary
      cd11972
      Location:413 → 473
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    2. NM_173143.2 → NP_775166.2  abl interactor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F1LYA6
      Conserved Domains (1) summary
      cd11972
      Location:384 → 444
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      69321072..69490630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266759.1 → XP_063122829.1  abl interactor 2 isoform X11

      UniProtKB/TrEMBL
      A6IPC6

    2. XM_063266783.1 → XP_063122853.1  abl interactor 2 isoform X33

      UniProtKB/TrEMBL
      A6IPC8

    3. XM_063266777.1 → XP_063122847.1  abl interactor 2 isoform X27

    4. XM_063266772.1 → XP_063122842.1  abl interactor 2 isoform X23

    5. XM_063266748.1 → XP_063122818.1  abl interactor 2 isoform X1

    6. XM_063266793.1 → XP_063122863.1  abl interactor 2 isoform X42

    7. XM_063266799.1 → XP_063122869.1  abl interactor 2 isoform X48

    8. XM_063266749.1 → XP_063122819.1  abl interactor 2 isoform X2

    9. XM_063266795.1 → XP_063122865.1  abl interactor 2 isoform X44

    10. XM_063266755.1 → XP_063122825.1  abl interactor 2 isoform X7

    11. XM_063266785.1 → XP_063122855.1  abl interactor 2 isoform X35

      Related
      ENSRNOP00000050008.7, ENSRNOT00000050179.7

    12. XM_063266756.1 → XP_063122826.1  abl interactor 2 isoform X8

    13. XM_063266768.1 → XP_063122838.1  abl interactor 2 isoform X19

      Related
      ENSRNOP00000099822.1, ENSRNOT00000162455.1

    14. XM_063266765.1 → XP_063122835.1  abl interactor 2 isoform X16

    15. XM_063266750.1 → XP_063122820.1  abl interactor 2 isoform X3

    16. XM_063266763.1 → XP_063122833.1  abl interactor 2 isoform X15

      Related
      ENSRNOP00000080678.2, ENSRNOT00000117396.2

    17. XM_063266771.1 → XP_063122841.1  abl interactor 2 isoform X22

    18. XM_063266767.1 → XP_063122837.1  abl interactor 2 isoform X18

    19. XM_063266784.1 → XP_063122854.1  abl interactor 2 isoform X34

    20. XM_063266754.1 → XP_063122824.1  abl interactor 2 isoform X6

    21. XM_063266762.1 → XP_063122832.1  abl interactor 2 isoform X14

    22. XM_063266766.1 → XP_063122836.1  abl interactor 2 isoform X17

    23. XM_063266798.1 → XP_063122868.1  abl interactor 2 isoform X47

    24. XM_063266774.1 → XP_063122844.1  abl interactor 2 isoform X25

      Related
      ENSRNOP00000112364.1, ENSRNOT00000149612.1

    25. XM_063266758.1 → XP_063122828.1  abl interactor 2 isoform X10

    26. XM_063266770.1 → XP_063122840.1  abl interactor 2 isoform X21

    27. XM_063266773.1 → XP_063122843.1  abl interactor 2 isoform X24

    28. XM_063266787.1 → XP_063122857.1  abl interactor 2 isoform X36

    29. XM_063266778.1 → XP_063122848.1  abl interactor 2 isoform X28

    30. XM_063266751.1 → XP_063122821.1  abl interactor 2 isoform X4

    31. XM_063266761.1 → XP_063122831.1  abl interactor 2 isoform X13

    32. XM_063266752.1 → XP_063122822.1  abl interactor 2 isoform X5

    33. XM_063266797.1 → XP_063122867.1  abl interactor 2 isoform X46

    34. XM_063266757.1 → XP_063122827.1  abl interactor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZLD3

    35. XM_063266769.1 → XP_063122839.1  abl interactor 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZQU4

    36. XM_063266776.1 → XP_063122846.1  abl interactor 2 isoform X26

    37. XM_063266760.1 → XP_063122830.1  abl interactor 2 isoform X12

      Related
      ENSRNOP00000078640.2, ENSRNOT00000096759.2

    38. XM_063266779.1 → XP_063122849.1  abl interactor 2 isoform X29

      UniProtKB/TrEMBL
      A0A8I5ZKW2

    39. XM_063266788.1 → XP_063122858.1  abl interactor 2 isoform X37

    40. XM_063266791.1 → XP_063122861.1  abl interactor 2 isoform X40

    41. XM_063266780.1 → XP_063122850.1  abl interactor 2 isoform X30

    42. XM_063266792.1 → XP_063122862.1  abl interactor 2 isoform X41

    43. XM_063266790.1 → XP_063122860.1  abl interactor 2 isoform X39

    44. XM_063266782.1 → XP_063122852.1  abl interactor 2 isoform X32

      Related
      ENSRNOP00000082875.2, ENSRNOT00000111854.2

    45. XM_063266794.1 → XP_063122864.1  abl interactor 2 isoform X43

    46. XM_063266789.1 → XP_063122859.1  abl interactor 2 isoform X38

    47. XM_063266781.1 → XP_063122851.1  abl interactor 2 isoform X31

      UniProtKB/TrEMBL
      A0A8I5ZVR4

    48. XM_063266796.1 → XP_063122866.1  abl interactor 2 isoform X45

    Nucleotide Protein Strain
    Heading Accession and Version

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