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    Dpp9 dipeptidyl peptidase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dpp9provided by RGD
    Official Full Name
    dipeptidyl peptidase 9provided by RGD
    Primary source
    RGD:1588575
    See related
    EnsemblRapid:ENSRNOG00000050748 AllianceGenome:RGD:1588575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dipeptidyl-peptidase activity and identical protein binding activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to act upstream of with a negative effect on pyroptotic inflammatory response. Predicted to be located in cell leading edge and microtubule. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 53.5), Muscle (RPKM 51.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpp9 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1098505..1133500, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1011347..1046337, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10846493..10882560)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene semaphorin 6B Neighboring gene TNF alpha induced protein 8 like 1 Neighboring gene uncharacterized LOC134480469 Neighboring gene myeloid-derived growth factor Neighboring gene uncharacterized LOC103693194 Neighboring gene large ribosomal subunit protein uL29-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Harstad EB, et al. Regul Pept, 2013 Sep 10. PMID 23850796
    2. Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues. Dubois V, et al. J Histochem Cytochem, 2009 Jun. PMID 19188489, Free PMC Article
    3. Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Zhang H, et al. Biochim Biophys Acta, 2015 Feb. PMID 25486458
    4. Structural and biochemical mechanisms of NLRP1 inhibition by DPP9. Huang M, et al. Nature, 2021 Apr. PMID 33731929, Free PMC Article
    5. Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9. Tang HK, et al. FEBS Lett, 2011 Nov 4. PMID 22001206

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
      Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
    2. DPP8 and DPP9 may act similarly across tissues, and that their actions might in part overlap with DPP4.
      Title: DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues.
    3. We showed the expression of DPP8 and DPP9 in the testis, epididymis, and sperm.
      Title: Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_negative_effect pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 9
    NP_001292170.1
    XP_038939073.1
    XP_217309.6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305241.1 → NP_001292170.1  dipeptidyl peptidase 9

      See identical proteins and their annotated locations for NP_001292170.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R781
      Related
      ENSRNOP00000084045.1, ENSRNOT00000104698.2
      Conserved Domains (2) summary
      pfam00326
      Location:661 → 862
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:145 → 569
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1098505..1133500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_217309.11 → XP_217309.6  dipeptidyl peptidase 9 isoform X1

      See identical proteins and their annotated locations for XP_217309.6

      UniProtKB/TrEMBL
      A0A8I6G9M9, M0R781
      Related
      ENSRNOP00000065303.3, ENSRNOT00000075386.5
      Conserved Domains (3) summary
      COG1073
      Location:671 → 921
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
      pfam00326
      Location:720 → 921
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:204 → 628
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. XM_039083145.2 → XP_038939073.1  dipeptidyl peptidase 9 isoform X2

      UniProtKB/TrEMBL
      M0R781
      Related
      ENSRNOP00000083924.2, ENSRNOT00000099824.2
      Conserved Domains (2) summary
      COG1506
      Location:525 → 785
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:145 → 569
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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