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    Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316611, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Agap1provided by RGD
    Official Full Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 1provided by RGD
    Primary source
    RGD:1309244
    See related
    EnsemblRapid:ENSRNOG00000019476 AllianceGenome:RGD:1309244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Centg2
    Summary
    Predicted to enable GTPase activator activity; GTPase activity; and phospholipid binding activity. Involved in regulation of modification of postsynaptic structure. Is active in postsynaptic endosome. Orthologous to several human genes including AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 97.6), Lung (RPKM 88.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agap1 in Genome Data Viewer
    Location:
    9q35-q36
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (97487382..97922870)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (90039720..90475196)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (96718901..97034400)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554475 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene uncharacterized LOC120094807 Neighboring gene uncharacterized LOC134480609 Neighboring gene uncharacterized LOC102554789 Neighboring gene gastrulation brain homeobox 2 Neighboring gene ankyrin repeat and SOCS box-containing 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. Bendor J, et al. EMBO J, 2010 Aug 18. PMID 20664521, Free PMC Article
    2. A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. Eberth A, et al. Biochem J, 2009 Jan 1. PMID 18954304
    3. The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin. Arnold M, et al. Front Cell Neurosci, 2016. PMID 27713690, Free PMC Article
    4. AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. Meurer S, et al. J Biol Chem, 2004 Nov 19. PMID 15381706
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction with AGAP1 and activity of adaptor protein 3 were required for the endocytic recycling of M5 muscarinic receptor in neurons.
      Title: AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.
    2. AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase
      Title: AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of modification of postsynaptic structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
    Names
    centaurin, gamma 2
    NP_001101700.2
    NP_001388522.1
    XP_006245464.2
    XP_017451979.1
    XP_017451982.1
    XP_038939672.1
    XP_038939674.1
    XP_038939679.1
    XP_038939680.1
    XP_063123367.1
    XP_063123368.1
    XP_063123369.1
    XP_063123370.1
    XP_063123371.1
    XP_063123372.1
    XP_063123373.1
    XP_063123374.1
    XP_063123375.1
    XP_063123376.1
    XP_063123377.1
    XP_063123378.1
    XP_063123379.1
    XP_063123380.1
    XP_063123381.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108230.2 → NP_001101700.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Related
      ENSRNOP00000060109.2, ENSRNOT00000065720.3

    2. NM_001401593.1 → NP_001388522.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      97487382..97922870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267308.1 → XP_063123378.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X17

    2. XM_063267307.1 → XP_063123377.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X16

      Related
      ENSRNOP00000074469.2, ENSRNOT00000088192.3

    3. XM_063267311.1 → XP_063123381.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X20

      Related
      ENSRNOP00000108422.1, ENSRNOT00000137621.1

    4. XM_063267309.1 → XP_063123379.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X18

      Related
      ENSRNOP00000104606.1, ENSRNOT00000128951.1

    5. XM_063267310.1 → XP_063123380.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X19

    6. XM_039083751.2 → XP_038939679.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A0G2K847
      Conserved Domains (5) summary
      cd04103
      Location:72 → 229
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      cd01250
      Location:344 → 539
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      sd00045
      Location:680 → 708
      ANK; ANK repeat [structural motif]
      cd08853
      Location:556 → 664
      ArfGap_AGAP2; ArfGAP with GTPase domain, ANK repeat and PH domain 2
      pfam12796
      Location:683 → 773
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_039083752.2 → XP_038939680.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A0G2K847
      Conserved Domains (5) summary
      cd04103
      Location:72 → 229
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      cd01250
      Location:344 → 485
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      sd00045
      Location:626 → 654
      ANK; ANK repeat [structural motif]
      cd08853
      Location:502 → 610
      ArfGap_AGAP2; ArfGAP with GTPase domain, ANK repeat and PH domain 2
      pfam12796
      Location:629 → 719
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_017596490.3 → XP_017451979.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1

    9. XM_063267298.1 → XP_063123368.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X3

    10. XM_063267299.1 → XP_063123369.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X4

      Related
      ENSRNOP00000108259.1, ENSRNOT00000163080.1

    11. XM_039083744.2 → XP_038939672.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AWZ3
      Conserved Domains (5) summary
      cd04103
      Location:561 → 722
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      cd01250
      Location:837 → 1031
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      sd00045
      Location:1172 → 1200
      ANK; ANK repeat [structural motif]
      cd08853
      Location:1048 → 1156
      ArfGap_AGAP2; ArfGAP with GTPase domain, ANK repeat and PH domain 2
      pfam12796
      Location:1175 → 1265
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_017596493.3 → XP_017451982.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X5

    13. XM_006245402.5 → XP_006245464.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X8

      Related
      ENSRNOP00000086357.2, ENSRNOT00000104807.2
      Conserved Domains (8) summary
      cd04103
      Location:561 → 722
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00173
      Location:562 → 728
      RAS; Ras subfamily of RAS small GTPases
      cd00204
      Location:1199 → 1288
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:837 → 1058
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:1001 → 1053
      PH; PH domain
      pfam01412
      Location:1077 → 1191
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:1202 → 1292
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1199 → 1227
      ANK; ANK repeat [structural motif]

    14. XM_063267303.1 → XP_063123373.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X10

    15. XM_039083746.2 → XP_038939674.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6GDZ1
      Conserved Domains (5) summary
      cd04103
      Location:561 → 722
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      cd01250
      Location:837 → 978
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      sd00045
      Location:1119 → 1147
      ANK; ANK repeat [structural motif]
      cd08853
      Location:995 → 1103
      ArfGap_AGAP2; ArfGAP with GTPase domain, ANK repeat and PH domain 2
      pfam12796
      Location:1122 → 1212
      Ank_2; Ankyrin repeats (3 copies)

    16. XM_063267297.1 → XP_063123367.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X2

    17. XM_063267304.1 → XP_063123374.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X12

    18. XM_063267306.1 → XP_063123376.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X15

    19. XM_063267302.1 → XP_063123372.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X9

    20. XM_063267305.1 → XP_063123375.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X13

    21. XM_063267300.1 → XP_063123370.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X6

      Related
      ENSRNOP00000093401.2, ENSRNOT00000105657.2

    22. XM_063267301.1 → XP_063123371.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X7

      Related
      ENSRNOP00000085146.2, ENSRNOT00000107897.2
    Nucleotide Protein Strain
    Heading Accession and Version

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