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    Stard8 StAR-related lipid transfer domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312113, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stard8provided by RGD
    Official Full Name
    StAR-related lipid transfer domain containing 8provided by RGD
    Primary source
    RGD:1560770
    See related
    EnsemblRapid:ENSRNOG00000033883 AllianceGenome:RGD:1560770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560770
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Orthologous to human STARD8 (StAR related lipid transfer domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 121.6), Heart (RPKM 57.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stard8 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (68119276..68236247)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (64079079..64196052)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (68713157..68785046)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484063 Neighboring gene Yip1 domain family, member 6 Neighboring gene ER membrane protein complex subunit 7, pseudogene 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein SA, pseudogene 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 8
    Names
    START domain containing 8
    StAR-related lipid transfer (START) domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107849.4 → NP_001101319.2  stAR-related lipid transfer protein 8

      See identical proteins and their annotated locations for NP_001101319.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IQ62
      Related
      ENSRNOP00000111209.1, ENSRNOT00000153437.1
      Conserved Domains (2) summary
      cl02570
      Location:560 → 774
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:801 → 1005
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      68119276..68236247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099691.2 → XP_038955619.1  stAR-related lipid transfer protein 8 isoform X3

      UniProtKB/TrEMBL
      A6IQ62
      Related
      ENSRNOP00000104319.1, ENSRNOT00000123604.1
      Conserved Domains (2) summary
      cl02570
      Location:560 → 774
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:801 → 1005
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. XM_006257074.5 → XP_006257136.1  stAR-related lipid transfer protein 8 isoform X2

      UniProtKB/TrEMBL
      D4A5B9
      Related
      ENSRNOP00000042131.4, ENSRNOT00000043872.6
      Conserved Domains (3) summary
      cd09538
      Location:31 → 90
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cl02570
      Location:640 → 854
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl14643
      Location:881 → 1085
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    3. XM_039099690.2 → XP_038955618.1  stAR-related lipid transfer protein 8 isoform X1

      Related
      ENSRNOP00000109884.1, ENSRNOT00000143878.1
      Conserved Domains (3) summary
      cd09538
      Location:73 → 132
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cl02570
      Location:682 → 896
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14643
      Location:923 → 1127
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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