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    Garem2 GRB2 associated regulator of MAPK1 subtype 2 [ Mus musculus (house mouse) ]

    Gene ID: 242915, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Garem2provided by MGI
    Official Full Name
    GRB2 associated regulator of MAPK1 subtype 2provided by MGI
    Primary source
    MGI:MGI:2685290
    See related
    Ensembl:ENSMUSG00000044576 AllianceGenome:MGI:2685290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm444; Fam59b; Gareml
    Summary
    Orthologous to human GAREM2 (GRB2 associated regulator of MAPK1 subtype 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 11.0), CNS E14 (RPKM 8.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Garem2 in Genome Data Viewer
    Location:
    5 B1; 5 15.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30310194..30323378)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30105196..30118380)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12746 Neighboring gene thymidylate synthase Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:30400119-30400228 Neighboring gene STARR-seq mESC enhancer starr_12748 Neighboring gene STARR-seq mESC enhancer starr_12749 Neighboring gene RIKEN cDNA 3110082J24 gene Neighboring gene kinesin superfamily protein 2C pseudogene Neighboring gene kinesin family member 2C pseudogene Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E8045 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene microRNA 1960

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain. Nishino T, et al. Mol Brain, 2019 Nov 12. PMID 31718706, Free PMC Article
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GAREM2 may have a common role related to the transduction of Erk signaling in the higher brain functions.
      Title: Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GRB2-associated and regulator of MAPK protein 2
    Names
    GRB2 associated, regulator of MAPK1-like
    GRB2-associated and regulator of MAPK protein-like
    GRB2-associated and regulator of MAPK1-like
    family with sequence similarity 59, member B
    protein FAM59B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167879.1 → NP_001161351.1  GRB2-associated and regulator of MAPK protein 2

      Status: VALIDATED

      Source sequence(s)
      BC060268, CJ217704, CX204487, CX237000
      Consensus CDS
      CCDS51449.1
      UniProtKB/Swiss-Prot
      Q14CH4, Q6PAJ3
      Related
      ENSMUSP00000054208.5, ENSMUST00000058045.5
      Conserved Domains (2) summary
      cd09525
      Location:812 → 878
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:29 → 338
      CABIT; Cell-cycle sustaining, positive selection,

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      30310194..30323378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PAJ3.2 GenPept UniProtKB/Swiss-Prot:Q6PAJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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