Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2c23provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily c, polypeptide 23provided by MGI
Primary source: MGI:MGI:1888897
See related: Ensembl:ENSMUSG00000025197 AllianceGenome:MGI:1888897
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp2c44; b2b386Clo
Summary: Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in epoxygenase P450 pathway; icosanoid biosynthetic process; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in metanephros; stomach; submandibular gland; and testis. Orthologous to human CYP2C23P (cytochrome P450 family 2 subfamily C member 23, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 77.1), liver E18 (RPKM 26.8) and 3 other tissues See more
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Genomic context

Location:: 19 C3; 19 36.69 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (43993461..44017695, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (44005022..44029256, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCdelta Axis.
Title: Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis.
Two members of dynamical network biomarke, PLA2G6 and CYP2C44 were found to induce dysfunction of arachidonic acid metabolism and finally lead to impairments of liver detoxification and malignant transition to cancer.
Title: Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma.
Role of Muller cell cytochrome P450 2c44 in murine retinal angiogenesis
Title: Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis.
Cytochrome P-450 2C44 plays a critical role in controlling the phenotype of hematopoietic stem cells and that when this enzyme is knocked out, stem cells are differentiated. These stem cells give rise to increased circulating monocytes and macrophages and contribute to the pathogenesis of chronic hypoxia-induced pulmonary artery remodeling and hypertension.
Title: Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.
study concludes that Cyp2c44 in the collecting duct is required for preventing the excessive Na(+) absorption induced by high K(+)intake by inhibition of ENaC and facilitating renal Na(+) excretion
Title: Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect.
The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt.
Title: The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt.
characterization of a role for the murine CYP2C44 epoxygenase and 14,15-EET in the ERK1/2-mediated regulation of amiloride-sensitive JNa+
Title: Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.
Cyp2c44 functions as an high potassium-inducible antihypertensive enzyme responsible for inhibiting ENaC activity and Na absorption in the aldosterone-sensitive distal nephron.
Title: Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake.
The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.
Title: The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.
Cyp2c44 arachidonic acid epoxygenase is a component of the signaling pathways associated with VEGF-stimulated angiogenesis
Title: The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (5) 1 citation

General gene information

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Markers

D0M19Mit112 (e-PCR)
- UniSTS:128328

D19Mit112 (e-PCR), detects polymorphism
- UniSTS:128328

NoName (e-PCR)
- UniSTS:237953

AW107714 (e-PCR)
- UniSTS:181242

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate 11,12-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate 14,15-epoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonate 14,15-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in epoxygenase P450 pathway	ISO Inferred from Sequence Orthology more info
involved_in icosanoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2C44

Names: Mutant line 386; arachidonic acid epoxygenase; cytochrome P450, 2c44; cytochrome P450, family 2, subfamily c, polypeptide 44

NP_001001446.3

EC 1.14.14.1

NP_001161377.1

EC 1.14.14.1

XP_017173651.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001446.3 → NP_001001446.3 cytochrome P450 2C44 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC124693, AK149451

Consensus CDS

CCDS29841.1

UniProtKB/Swiss-Prot

E9Q5K4, Q6IEF7, Q8BWN7, Q8QZW4

UniProtKB/TrEMBL

Q8CIE7

Related

ENSMUSP00000026211.9, ENSMUST00000026211.10

Conserved Domains (1) summary

cd20665
Location:65 → 489

CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s
NM_001167905.1 → NP_001161377.1 cytochrome P450 2C44 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC124693, AK050436

Consensus CDS

CCDS84445.1

UniProtKB/TrEMBL

Q3UEM4

Related

ENSMUSP00000148377.2, ENSMUST00000211830.2

Conserved Domains (1) summary

pfam00067
Location:34 → 445

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

43993461..44017695 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318162.1 → XP_017173651.1 cytochrome P450 2C44 isoform X1

UniProtKB/TrEMBL

Q8CIE7

Conserved Domains (1) summary

pfam00067
Location:34 → 496

p450; Cytochrome P450