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    Lcorl ligand dependent nuclear receptor corepressor-like [ Mus musculus (house mouse) ]

    Gene ID: 209707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lcorlprovided by MGI
    Official Full Name
    ligand dependent nuclear receptor corepressor-likeprovided by MGI
    Primary source
    MGI:MGI:2651932
    See related
    Ensembl:ENSMUSG00000015882 AllianceGenome:MGI:2651932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlr1; Gm3414
    Summary
    Predicted to enable histone methyltransferase binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; oocyte; retina; and trunk somite. Orthologous to human LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 2.2), CNS E18 (RPKM 2.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lcorl in Genome Data Viewer
    Location:
    5 B3; 5 25.31 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (45854523..46015213, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (45697181..45857835, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13005 Neighboring gene RIKEN cDNA 1600023N17 gene Neighboring gene STARR-positive B cell enhancer ABC_E1300 Neighboring gene DDB1 and CUL4 associated factor 16 pseudogene Neighboring gene non-SMC condensin I complex, subunit G Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene DNA-directed RNA polymerase III subunit RPC6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:46248894-46249195 Neighboring gene RIKEN cDNA 4930405L22 gene Neighboring gene STARR-seq mESC enhancer starr_13008 Neighboring gene predicted gene, 40298

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells. Takayanagi-Kiya S, et al. Zoolog Sci, 2014 Nov. PMID 25366156
    2. Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1). Kunieda T, et al. FEBS Lett, 2003 Jan 30. PMID 12560079
    3. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article
    4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner.
      Title: Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells.
    2. identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed predominantly in the spermatocytes of the testis
      Title: Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ligand-dependent nuclear receptor corepressor-like protein
    Names
    LCoR-like protein
    Mblk1-related protein-1
    mblk1-related protein 1
    transcription factor MLR1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163073.2 → NP_001156545.1  ligand-dependent nuclear receptor corepressor-like protein isoform 1

      See identical proteins and their annotated locations for NP_001156545.1

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Consensus CDS
      CCDS51499.1
      UniProtKB/Swiss-Prot
      B2RRS7, Q3U285, Q6NZG1, Q8BNH5, Q8BRN7, Q8BRT8, Q8C9J6, Q8CJG4
      Related
      ENSMUSP00000016026.8, ENSMUST00000016026.14
      Conserved Domains (1) summary
      pfam05225
      Location:525 → 570
      HTH_psq; helix-turn-helix, Psq domain

    2. NM_001359871.2 → NP_001346800.1  ligand-dependent nuclear receptor corepressor-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      UniProtKB/TrEMBL
      A0A0H2UH31
      Related
      ENSMUSP00000140503.3, ENSMUST00000190036.7

    3. NM_001359872.2 → NP_001346801.1  ligand-dependent nuclear receptor corepressor-like protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Consensus CDS
      CCDS89917.1
      UniProtKB/TrEMBL
      E9PXY2, Q8C9B1
      Related
      ENSMUSP00000112416.2, ENSMUST00000121573.8

    4. NM_001359873.2 → NP_001346802.1  ligand-dependent nuclear receptor corepressor-like protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Related
      ENSMUST00000067997.11

    5. NM_001359874.2 → NP_001346803.1  ligand-dependent nuclear receptor corepressor-like protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      UniProtKB/TrEMBL
      A0A087WST0

    6. NM_001428433.1 → NP_001415362.1  ligand-dependent nuclear receptor corepressor-like protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      UniProtKB/TrEMBL
      A0A571BEC4

    7. NM_001428434.1 → NP_001415363.1  ligand-dependent nuclear receptor corepressor-like protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    8. NM_001428435.1 → NP_001415364.1  ligand-dependent nuclear receptor corepressor-like protein isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    9. NM_001428436.1 → NP_001415365.1  ligand-dependent nuclear receptor corepressor-like protein isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    10. NM_001428437.1 → NP_001415366.1  ligand-dependent nuclear receptor corepressor-like protein isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    11. NM_001428438.1 → NP_001415367.1  ligand-dependent nuclear receptor corepressor-like protein isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    12. NM_001428439.1 → NP_001415368.1  ligand-dependent nuclear receptor corepressor-like protein isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      UniProtKB/TrEMBL
      A0A0H2UH31

    13. NM_001428440.1 → NP_001415369.1  ligand-dependent nuclear receptor corepressor-like protein isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    14. NM_001428441.1 → NP_001415370.1  ligand-dependent nuclear receptor corepressor-like protein isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    15. NM_001428442.1 → NP_001415371.1  ligand-dependent nuclear receptor corepressor-like protein isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    16. NM_001428443.1 → NP_001415372.1  ligand-dependent nuclear receptor corepressor-like protein isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    17. NM_001428444.1 → NP_001415373.1  ligand-dependent nuclear receptor corepressor-like protein isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786

    18. NM_172153.4 → NP_742165.1  ligand-dependent nuclear receptor corepressor-like protein isoform 2

      See identical proteins and their annotated locations for NP_742165.1

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Consensus CDS
      CCDS19278.1
      UniProtKB/Swiss-Prot
      Q3U285
      Related
      ENSMUSP00000084408.4, ENSMUST00000087164.10
      Conserved Domains (1) summary
      pfam05225
      Location:442 → 487
      HTH_psq; helix-turn-helix, Psq domain

    19. NM_178142.6 → NP_835278.2  ligand-dependent nuclear receptor corepressor-like protein isoform 3

      See identical proteins and their annotated locations for NP_835278.2

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Consensus CDS
      CCDS19277.1
      UniProtKB/Swiss-Prot
      Q3U285
      Related
      ENSMUSP00000042677.7, ENSMUST00000045586.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      45854523..46015213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      45877009..45884920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503818.5 → XP_006503881.1  ligand-dependent nuclear receptor corepressor-like protein isoform X1

      Related
      ENSMUSP00000158672.2, ENSMUST00000238522.2
      Conserved Domains (1) summary
      pfam15090
      Location:1402 → 1846
      DUF4553; Domain of unknown function (DUF4553)

    2. XM_036164968.1 → XP_036020861.1  ligand-dependent nuclear receptor corepressor-like protein isoform X2

      Conserved Domains (1) summary
      pfam15090
      Location:1332 → 1776
      DUF4553; Domain of unknown function (DUF4553)

    3. XM_030254342.2 → XP_030110202.1  ligand-dependent nuclear receptor corepressor-like protein isoform X7

      UniProtKB/TrEMBL
      E9PXY2, Q8C9B1

    4. XM_036164972.1 → XP_036020865.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      Conserved Domains (1) summary
      pfam05225
      Location:366 → 411
      HTH_psq; helix-turn-helix, Psq domain

    5. XM_030254341.2 → XP_030110201.1  ligand-dependent nuclear receptor corepressor-like protein isoform X5

      Conserved Domains (1) summary
      pfam05225
      Location:439 → 484
      HTH_psq; helix-turn-helix, Psq domain

    6. XM_036164971.1 → XP_036020864.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      Conserved Domains (1) summary
      pfam05225
      Location:366 → 411
      HTH_psq; helix-turn-helix, Psq domain

    7. XM_036164970.1 → XP_036020863.1  ligand-dependent nuclear receptor corepressor-like protein isoform X4

      Conserved Domains (1) summary
      pfam05225
      Location:442 → 487
      HTH_psq; helix-turn-helix, Psq domain

    8. XM_036164969.1 → XP_036020862.1  ligand-dependent nuclear receptor corepressor-like protein isoform X3

      Conserved Domains (1) summary
      pfam05225
      Location:455 → 500
      HTH_psq; helix-turn-helix, Psq domain

    9. XM_030254345.2 → XP_030110205.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

      UniProtKB/TrEMBL
      A0A0H2UH31

    10. XM_030254343.2 → XP_030110203.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

    11. XM_030254344.1 → XP_030110204.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

    RNA

    1. XR_004942478.1 RNA Sequence

    2. XR_004942488.1 RNA Sequence

    3. XR_004942487.1 RNA Sequence

    4. XR_004942483.1 RNA Sequence

    5. XR_004942479.1 RNA Sequence

    6. XR_004942482.1 RNA Sequence

    7. XR_004942481.1 RNA Sequence

    8. XR_004942484.1 RNA Sequence

    9. XR_004942480.1 RNA Sequence

    10. XR_004942485.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U285.1 GenPept UniProtKB/Swiss-Prot:Q3U285

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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