Zfp57 zinc finger protein 57 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp57provided by MGI
Official Full Name: zinc finger protein 57provided by MGI
Primary source: MGI:MGI:99204
See related: Ensembl:ENSMUSG00000036036 AllianceGenome:MGI:99204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G19; Zfp-57
Summary: Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in autosome genomic imprinting; epigenetic programing of female pronucleus; and negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within epigenetic programming in the zygotic pronuclei; genomic imprinting; and negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and retina. Orthologous to human ZFP57 (ZFP57 zinc finger protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 66.8), CNS E14 (RPKM 62.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 19.16 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (37307060..37326196)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (37001163..37010729)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo.
Title: Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo.
Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs.
Title: Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs.
A group of functionally significant composite DNA elements (ZFP57 binding site (ZFBS)-Morph overlaps) that may play dual roles in the regulation of allele-specific gene expression.
Title: Imprinted control regions include composite DNA elements consisting of the ZFP57 binding site overlapping MLL1 morphemes.
another function of ZFP57 in early embryogenesis is to repress cis-acting regulatory elements whose activity is not yet required.
Title: ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells.
Data show that ZFP57 binding is affected by single nucleotide polymorphism (SNPs) and closely associated TGCCGC motif sequences that are present at the target sites.
Title: ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells.
Within established mouse imprinted clusters, ZFP57 specifically binds known or predicted imprinting control region elements, but does not interact with secondary somatically differentially methylated regions (DMRs) or germline DMRs that are not imprinting controlling.
Title: Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.
ZFP57 may modulate NOTCH signaling during cardiac development.
Title: Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Taken together, our results suggest that Nanog positively regulates Zfp57 expression in multiple types of cells.
Title: Nanog positively regulates Zfp57 expression in mouse embryonic stem cells.
Mouse and human ZFP57 are orthologs despite relatively low sequence identity.
Title: Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cells.
Data suggest that Glu182 in the DNA binding site in zinc finger motif of Zfp57 plays important role in binding specificity and affinity for 5-carboxylcytosine and other cytosine analogs.
Title: DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mog (e-PCR), detects polymorphism
- UniSTS:143893

NoName (e-PCR)
- UniSTS:237644

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded methylated DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within autosome genomic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autosome genomic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autosome genomic imprinting	ISO Inferred from Sequence Orthology more info
involved_in epigenetic programing of female pronucleus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epigenetic programming in the zygotic pronuclei	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within genomic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013745.2 → NP_001013767.1 zinc finger protein 57 isoform 1

See identical proteins and their annotated locations for NP_001013767.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.

Source sequence(s)

BC052028, CF731693, CR956641

Consensus CDS

CCDS28733.1

UniProtKB/Swiss-Prot

Q3UT94, Q62515, Q6JPI1, Q8C6P8

Related

ENSMUSP00000065811.8, ENSMUST00000069250.14

Conserved Domains (4) summary

smart00349
Location:15 → 72

KRAB; krueppel associated box

COG5048
Location:139 → 309

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:92 → 134

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:169 → 190

zf-C2H2; Zinc finger, C2H2 type
NM_001168501.1 → NP_001161973.1 zinc finger protein 57 isoform 1

See identical proteins and their annotated locations for NP_001161973.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AV579696, BC052028, CR956641

Consensus CDS

CCDS28733.1

UniProtKB/Swiss-Prot

Q3UT94, Q62515, Q6JPI1, Q8C6P8

Related

ENSMUSP00000134418.2, ENSMUST00000174524.8

Conserved Domains (4) summary

smart00349
Location:15 → 72

KRAB; krueppel associated box

COG5048
Location:139 → 309

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:92 → 134

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:169 → 190

zf-C2H2; Zinc finger, C2H2 type
NM_001168502.1 → NP_001161974.1 zinc finger protein 57 isoform 2

See identical proteins and their annotated locations for NP_001161974.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs at the 5' end and uses an alternate, in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in a shorter isoform (2) missing three internal aa compared to isoform 1.

Source sequence(s)

AK139625, BC052028, CR956641

Consensus CDS

CCDS50106.1

UniProtKB/Swiss-Prot

Q8C6P8

Related

ENSMUSP00000087414.7, ENSMUST00000089968.13

Conserved Domains (4) summary

smart00349
Location:12 → 69

KRAB; krueppel associated box

COG5048
Location:136 → 306

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:89 → 131

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:166 → 187

zf-C2H2; Zinc finger, C2H2 type

RNA

NR_033137.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs at the 5' end compared to variant 1, and contains an upstream ORF with a strong Kozak signal, which according to leaky scanning model could interfere with the translation of the downstream primary ORF. Translation from the upstream ORF will render this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, this variant transcript is sufficiently abundant to represent as a non-coding RefSeq record.

Source sequence(s)

AK143118, BC052028, CR956641

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

37307060..37326196

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160583.1 → XP_036016476.1 zinc finger protein 57 isoform X2

Conserved Domains (4) summary

smart00349
Location:12 → 69

KRAB; krueppel associated box

COG5048
Location:136 → 306

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:89 → 131

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:166 → 187

zf-C2H2; Zinc finger, C2H2 type
XM_036160582.1 → XP_036016475.1 zinc finger protein 57 isoform X1

UniProtKB/Swiss-Prot

Q3UT94, Q62515, Q6JPI1, Q8C6P8

Conserved Domains (4) summary

smart00349
Location:15 → 72

KRAB; krueppel associated box

COG5048
Location:139 → 309

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:92 → 134

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:169 → 190

zf-C2H2; Zinc finger, C2H2 type
XM_036160584.1 → XP_036016477.1 zinc finger protein 57 isoform X2

Conserved Domains (4) summary

smart00349
Location:12 → 69

KRAB; krueppel associated box

COG5048
Location:136 → 306

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:89 → 131

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:166 → 187

zf-C2H2; Zinc finger, C2H2 type

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_009559.2: Suppressed sequence

Description

NM_009559.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.