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    Kcnc1 potassium voltage-gated channel subfamily C member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25327, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnc1provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily C member 1provided by RGD
    Primary source
    RGD:2955
    See related
    EnsemblRapid:ENSRNOG00000055401 AllianceGenome:RGD:2955
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv4; Kv3.1; KShIIIB; NGK2-KV4
    Summary
    Enables delayed rectifier potassium channel activity; transmembrane transporter binding activity; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including nervous system development; positive regulation of voltage-gated potassium channel activity; and response to auditory stimulus. Located in several cellular components, including cell surface; neuron projection membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in calyx of Held; postsynaptic membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 66.9) and Muscle (RPKM 19.9) See more
    Orthologs
    NEW
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    Genomic context

    See Kcnc1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (106039247..106081034)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96902953..96944744)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102414352..102456718)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485120 Neighboring gene otogelin Neighboring gene uncharacterized LOC120099806 Neighboring gene myogenic differentiation 1 Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene uncharacterized LOC134485121 Neighboring gene uncharacterized LOC120099808

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in corpus callosum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in globus pallidus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in optic nerve development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein tetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of monoatomic ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to auditory stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fibroblast growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to light intensity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nerve growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to potassium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal cell body membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    voltage-gated potassium channel KCNC1
    Names
    NGK2
    Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991)
    RAW2
    potassium channel, voltage gated Shaw-related subfamily C, member 1
    potassium voltage gated channel, Shaw-related subfamily, member 1
    voltage-gated potassium channel subunit Kv3.1
    voltage-gated potassium channel subunit Kv4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012856.3NP_036988.1  voltage-gated potassium channel KCNC1

      See identical proteins and their annotated locations for NP_036988.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P25122
      Related
      ENSRNOP00000074146.1, ENSRNOT00000089488.3
      Conserved Domains (2) summary
      cd18414
      Location:6122
      BTB_KCNC1_3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3
      pfam00520
      Location:189447
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      106039247..106081034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)