Arhgef7 Rho guanine nucleotide exchange factor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgef7provided by RGD
Official Full Name: Rho guanine nucleotide exchange factor 7provided by RGD
Primary source: RGD:620624
See related: EnsemblRapid:ENSRNOG00000012934 AllianceGenome:RGD:620624
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P85spr; Pak3bp
Summary: Enables protein kinase binding activity. Contributes to small GTPase binding activity. Involved in actin cytoskeleton organization; astrocyte cell migration; and small GTPase-mediated signal transduction. Located in focal adhesion and growth cone. Part of protein-containing complex. Is active in GABA-ergic synapse. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 45.3), Lung (RPKM 43.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (84373123..84484759, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (77671021..77782593, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (83006732..83117065, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells.
Title: β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells.
Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor beta-PIX in developing hippocampal neurons.
Title: Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons.
Kinesin-1-dependent transport of the betaPIX/GIT complex in neuronal cells.
Title: Kinesin-1-dependent transport of the βPIX/GIT complex in neuronal cells.
Induced association of beta-PIX with GIT1 is essential for the stimulation of intestinal epithelial restitution by activating Rac1, and this signaling pathway is tightly regulated by cellular polyamines.
Title: β-PIX plays an important role in regulation of intestinal epithelial restitution by interacting with GIT1 and Rac1 after wounding.
NM II maintains proper morphology of neuronal growth cones and the distal axon by regulating actin dynamics through the guanine nucleotide exchange factor-Rho GTPase signaling pathway.
Title: Non-muscle myosin II regulates neuronal actin dynamics by interacting with guanine nucleotide exchange factors.
Therefore, we propose that PKCgamma positively modulates dopamine release through beta2PIX phosphorylation.
Title: The role of Pak-interacting exchange factor-β phosphorylation at serines 340 and 583 by PKCγ in dopamine release.
beta-pix forms a complex with cadherin, beta-catenin, and scribble at synapses and enhances localized actin polymerization in rat hippocampal neurons.
Title: β-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses.
Intersectin-1L and beta-Pix, play essential roles in neuroendocrine exocytosis by controlling the activity of Cdc42 and Rac1, respectively.
Title: The Rho guanine nucleotide exchange factors Intersectin 1L and β-Pix control calcium-regulated exocytosis in neuroendocrine PC12 cells.
betaPix is not involved in the acute effect of ET-1 on channel open probability but instead mediates chronic decrease of number of active channels.
Title: Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2.
Despite the fact that the betaPIX coiled-coil domain exposes three PDZ binding motifs in the C-termini, the betaPIX trimer associates with a single Shank PDZ.
Title: Structural basis for asymmetric association of the betaPIX coiled coil and shank PDZ.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136837 (e-PCR)
- UniSTS:218926

Arhgef7 (e-PCR), detects polymorphism
- UniSTS:496708

D16Rat126 (e-PCR), detects polymorphism
- UniSTS:226783

RH143440 (e-PCR)
- UniSTS:232687

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables gamma-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
contributes_to small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in astrocyte cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of growth hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in storage vacuole	IEA Inferred from Electronic Annotation more info
located_in storage vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 7

Names: PAK-interacting exchange factor beta; Rho guanine nucleotide exchange factor (GEF) 7; beta-Pix

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113521.3 → NP_001106993.3 rho guanine nucleotide exchange factor 7 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2QC21

Related

ENSRNOP00000095285.2, ENSRNOT00000100639.2
NM_001113522.3 → NP_001106994.3 rho guanine nucleotide exchange factor 7 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2QC21

Related

ENSRNOP00000017947.6, ENSRNOT00000017947.6
NM_053740.4 → NP_446192.4 rho guanine nucleotide exchange factor 7 isoform c

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2QC21

Related

ENSRNOP00000103841.1, ENSRNOT00000171130.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

84373123..84484759 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274984.1 → XP_063131054.1 rho guanine nucleotide exchange factor 7 isoform X3

UniProtKB/TrEMBL

A0A8L2Q927
XM_008771380.3 → XP_008769602.3 rho guanine nucleotide exchange factor 7 isoform X1

UniProtKB/TrEMBL

A0A8I6AP31
XM_063274985.1 → XP_063131055.1 rho guanine nucleotide exchange factor 7 isoform X5

UniProtKB/TrEMBL

A0A8L2Q927
XM_039094099.2 → XP_038950027.2 rho guanine nucleotide exchange factor 7 isoform X2

UniProtKB/TrEMBL

A0A8I6AP31
XM_039094100.2 → XP_038950028.2 rho guanine nucleotide exchange factor 7 isoform X7

UniProtKB/TrEMBL

A3KMH4, F1LNB0, Q52NK0
XM_063274987.1 → XP_063131057.1 rho guanine nucleotide exchange factor 7 isoform X8

UniProtKB/Swiss-Prot

O55043

UniProtKB/TrEMBL

A6IWN1
XM_008771376.4 → XP_008769598.3 rho guanine nucleotide exchange factor 7 isoform X4

UniProtKB/TrEMBL

A3KMH4
XM_063274986.1 → XP_063131056.1 rho guanine nucleotide exchange factor 7 isoform X6

UniProtKB/Swiss-Prot

O55043

UniProtKB/TrEMBL

A6IWN1

Related

ENSRNOP00000043761.7, ENSRNOT00000043449.8
XM_063274988.1 → XP_063131058.1 rho guanine nucleotide exchange factor 7 isoform X9

UniProtKB/TrEMBL

A3KMH4