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    PRNP prion protein [ Pan troglodytes (chimpanzee) ]

    Gene ID: 458076, updated on 3-Dec-2024

    Summary

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    Official Symbol
    PRNPprovided by VGNC
    Official Full Name
    prion proteinprovided by VGNC
    Primary source
    VGNC:VGNC:6248
    Locus tag
    CK820_G0017514
    See related
    Ensembl:ENSPTRG00000046640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    PrP; CD230; PrP27-30; PrP33-35C
    Summary
    In human, the protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 Kb upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. In human, mutations in the repeat region as well as elsewhere in the gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Orthologs
    human mouse all
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    Genomic context

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    See PRNP in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 21 NC_072419.2 (11283848..11299337)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 20 NC_072418.1 (11295328..11310626)

    Chromosome 21 - NC_072419.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134809161 Neighboring gene small ribosomal subunit protein eS4, X isoform-like Neighboring gene uncharacterized LOC107969932 Neighboring gene prion like protein doppel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variation of the prion gene in chimpanzees and its implication for prion diseases. Soldevila M, et al. Neurosci Lett, 2004 Jan 30. PMID 14732455
    2. Infectious amyloid precursor gene sequences in primates used for experimental transmission of human spongiform encephalopathy. Cervenáková L, et al. Proc Natl Acad Sci U S A, 1994 Dec 6. PMID 7991600, Free PMC Article
    3. Prion protein gene variation among primates. Schätzl HM, et al. J Mol Biol, 1995 Jan 27. PMID 7837269
    4. An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein. Vanderperre B, et al. FASEB J, 2011 Jul. PMID 21478263
    5. Mapping of chimpanzee full-length cDNAs onto the human genome unveils large potential divergence of the transcriptome. Sakate R, et al. Gene, 2007 Sep 1. PMID 17574350

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major prion protein
    Names
    CD230 antigen
    infectious amyloid

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009093.6 → NP_001009093.1  major prion protein preproprotein

      See identical proteins and their annotated locations for NP_001009093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAQQLN020000021
      UniProtKB/Swiss-Prot
      P40253, P61768
      UniProtKB/TrEMBL
      A0A2J8MSH1, A0A2J8MSH5, A5A6I7
      Conserved Domains (2) summary
      smart00157
      Location:23 → 240
      PRP; Major prion protein
      pfam11587
      Location:1 → 28
      Prion_bPrPp; Major prion protein bPrPp - N terminal

    2. NM_001110206.5 → NP_001103676.1  major prion protein preproprotein

      See identical proteins and their annotated locations for NP_001103676.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAQQLN020000021
      UniProtKB/Swiss-Prot
      P40253, P61768
      UniProtKB/TrEMBL
      A0A2J8MSH1, A0A2J8MSH5, A5A6I7
      Related
      ENSPTRP00000075233.1, ENSPTRT00000080287.1
      Conserved Domains (2) summary
      smart00157
      Location:23 → 240
      PRP; Major prion protein
      pfam11587
      Location:1 → 28
      Prion_bPrPp; Major prion protein bPrPp - N terminal

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072419.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      11283848..11299337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009436630.5 → XP_009434905.1  major prion protein isoform X1

      See identical proteins and their annotated locations for XP_009434905.1

      UniProtKB/Swiss-Prot
      P40253, P61768
      UniProtKB/TrEMBL
      A0A2J8MSH1, A0A2J8MSH5, A5A6I7
      Conserved Domains (2) summary
      smart00157
      Location:23 → 240
      PRP; Major prion protein
      pfam11587
      Location:1 → 28
      Prion_bPrPp; Major prion protein bPrPp - N terminal

    2. XM_009436631.5 → XP_009434906.1  major prion protein isoform X1

      See identical proteins and their annotated locations for XP_009434906.1

      UniProtKB/Swiss-Prot
      P40253, P61768
      UniProtKB/TrEMBL
      A0A2J8MSH1, A0A2J8MSH5, A5A6I7
      Conserved Domains (2) summary
      smart00157
      Location:23 → 240
      PRP; Major prion protein
      pfam11587
      Location:1 → 28
      Prion_bPrPp; Major prion protein bPrPp - N terminal

    3. XM_063802406.1 → XP_063658476.1  major prion protein isoform X1

      UniProtKB/Swiss-Prot
      P40253, P61768
      UniProtKB/TrEMBL
      A0A2J8MSH1, A0A2J8MSH5, A5A6I7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61768.1 GenPept UniProtKB/Swiss-Prot:P61768

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