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    Snx33 sorting nexin 33 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx33provided by RGD
    Official Full Name
    sorting nexin 33provided by RGD
    Primary source
    RGD:1307898
    See related
    EnsemblRapid:ENSRNOG00000017382 AllianceGenome:RGD:1307898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sh3px3
    Summary
    Predicted to enable identical protein binding activity and phosphatidylinositol binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; plasma membrane tubulation; and regulation of protein localization to cell surface. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. Orthologous to human SNX33 (sorting nexin 33). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 192.7), Lung (RPKM 148.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx33 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66213133..66224926, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57315861..57328522, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61584656..61596055, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480055 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene transfer RNA proline (anticodon AGG) 41 Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene ribosomal protein S15a like 7 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. Wang JT, et al. PLoS One, 2010 Oct 29. PMID 21048941, Free PMC Article
    2. Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. Dislich B, et al. Biochem J, 2011 Jan 1. PMID 20964629
    3. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. Zhang J, et al. J Biol Chem, 2009 Aug 7. PMID 19487689, Free PMC Article
    4. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. Ma MP, et al. J Cell Sci, 2012 Sep 15. PMID 22718350
    5. The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. Heiseke A, et al. Traffic, 2008 Jul. PMID 18419754

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macropinocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-33
    Names
    SH3 and PX domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127488.2 → NP_001120960.1  sorting nexin-33

      See identical proteins and their annotated locations for NP_001120960.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4R8, D4A3X7
      Related
      ENSRNOP00000023428.3, ENSRNOT00000023428.6
      Conserved Domains (3) summary
      cd07669
      Location:365 → 571
      BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
      cd11896
      Location:4 → 58
      SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
      cl02563
      Location:230 → 354
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. NM_001429233.1 → NP_001416162.1  sorting nexin-33

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4R8, D4A3X7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66213133..66224926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243123.5 → XP_006243185.1  sorting nexin-33 isoform X1

      Conserved Domains (3) summary
      cd07669
      Location:365 → 571
      BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
      cd11896
      Location:4 → 58
      SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
      cl02563
      Location:230 → 354
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version

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