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    EPHB2 EPH receptor B2 [ Homo sapiens (human) ]

    Gene ID: 2048, updated on 10-Dec-2024

    Summary

    Official Symbol
    EPHB2provided by HGNC
    Official Full Name
    EPH receptor B2provided by HGNC
    Primary source
    HGNC:HGNC:3393
    See related
    Ensembl:ENSG00000133216 MIM:600997; AllianceGenome:HGNC:3393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; BDPLT22
    Summary
    This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
    Expression
    Broad expression in colon (RPKM 7.3), small intestine (RPKM 5.2) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EPHB2 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (22710838..22921500)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (22535722..22747006)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23037331..23247993)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:23003627-23004149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23004182-23004720 Neighboring gene complement C1q C chain Neighboring gene complement C1q B chain Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23021074-23021574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23021575-23022075 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23036019-23036304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23043657-23044346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23049783-23050297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23063222-23063783 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23066264-23066434 Neighboring gene microRNA 4684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 355 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23082861-23083022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23117273-23117773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23118959-23119488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23136274-23136774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23136775-23137275 Neighboring gene Sharpr-MPRA regulatory region 697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23154258-23154779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:23163087-23164034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23176387-23176888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23176889-23177388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23179771-23180334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23180335-23180896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 403 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23191518-23191863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:23203195-23203794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23206043-23206947 Neighboring gene uncharacterized LOC124903874 Neighboring gene microRNA 4253 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23216005-23216210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23251233-23251733 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23256871-23257055 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23287810-23287985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23290925-23291425 Neighboring gene lactamase beta like 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:23336854-23338053 Neighboring gene testis expressed 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of EPH receptor B2 (EPHB2) in peptide-treated PBMCs PubMed
    Nef nef HIV-1 Nef rapidly terminates ERK activation in the presence of TPA in a macrophage-inducing system PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC87492

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amyloid-beta binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables axon guidance receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane-ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane-ephrin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axonal fasciculation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amyloid-beta IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system projection neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in commissural neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in corpus callosum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hindbrain tangential cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner ear morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in learning or memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron projection retraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in optic nerve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic membrane assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of T-helper 17 type immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect regulation of autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of body fluid levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retinal ganglion cell axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in roof of mouth development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urogenital system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated intercellular transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynapse TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ephrin type-B receptor 2
    Names
    EPH-like kinase 5
    developmentally-regulated Eph-related tyrosine kinase
    elk-related tyrosine kinase
    eph tyrosine kinase 3
    protein-tyrosine kinase HEK5
    renal carcinoma antigen NY-REN-47
    tyrosine-protein kinase TYRO5
    tyrosine-protein kinase receptor EPH-3
    NP_001296121.1
    NP_001296122.1
    NP_004433.2
    NP_059145.2
    XP_006710504.1
    XP_006710505.1
    XP_047305060.1
    XP_054191013.1
    XP_054191014.1
    XP_054191015.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011804.2 RefSeqGene

      Range
      5001..215663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_780

    mRNA and Protein(s)

    1. NM_001309192.2NP_001296121.1  ephrin type-B receptor 2 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
      Source sequence(s)
      AL035704, AL158086, AL512444
      UniProtKB/TrEMBL
      B4DSE0
      Conserved Domains (5) summary
      cd05065
      Location:558826
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:852922
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437519
      fn3; Fibronectin type III domain
      pfam14575
      Location:500558
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. NM_001309193.2NP_001296122.1  ephrin type-B receptor 2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001296122.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site at an internal exon and alternate splice sites in the 3' coding region and 3' UTR, which results in a longer and novel 3' coding region compared to variant 2. It encodes isoform 4, which is longer than and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AL035704, AL158086, AL512444
      Consensus CDS
      CCDS81279.1
      UniProtKB/Swiss-Prot
      O43477, P29323, Q5T0U6, Q5T0U7, Q5T0U8
      UniProtKB/TrEMBL
      Q4LE53
      Related
      ENSP00000383053.3, ENST00000400191.7
      Conserved Domains (7) summary
      cd05065
      Location:616884
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:910980
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:910977
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437520
      fn3; Fibronectin type III domain
      pfam07714
      Location:621880
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:548616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    3. NM_004442.7NP_004433.2  ephrin type-B receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_004433.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. It encodes isoform 2.
      Source sequence(s)
      AK025975, AL035704, BC067861, DB282024, L41939
      Consensus CDS
      CCDS230.1
      UniProtKB/TrEMBL
      Q4LE53
      Related
      ENSP00000363763.3, ENST00000374632.7
      Conserved Domains (5) summary
      cd05065
      Location:617885
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:911981
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437519
      fn3; Fibronectin type III domain
      pfam14575
      Location:548617
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    4. NM_017449.5NP_059145.2  ephrin type-B receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_059145.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 2. It encodes isoform 1, which is shorter than isoform 2.
      Source sequence(s)
      AL035704, AL158086, AL512444
      Consensus CDS
      CCDS229.2
      UniProtKB/TrEMBL
      Q4LE53
      Related
      ENSP00000363761.3, ENST00000374630.8
      Conserved Domains (5) summary
      cd05065
      Location:616884
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:910980
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437519
      fn3; Fibronectin type III domain
      pfam14575
      Location:548616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      22710838..22921500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710442.5XP_006710505.1  ephrin type-B receptor 2 isoform X2

      UniProtKB/TrEMBL
      Q4LE53
      Conserved Domains (7) summary
      cd05065
      Location:586854
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:880950
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:880947
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:326421
      fn3; Fibronectin type III domain
      pfam07714
      Location:591850
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:517586
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. XM_047449104.1XP_047305060.1  ephrin type-B receptor 2 isoform X3

      UniProtKB/TrEMBL
      Q4LE53
    3. XM_006710441.5XP_006710504.1  ephrin type-B receptor 2 isoform X1

      UniProtKB/TrEMBL
      Q4LE53
      Conserved Domains (7) summary
      cd05065
      Location:610878
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:904974
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:904971
      SAM; Sterile alpha motif
      cd10477
      Location:12189
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:430513
      fn3; Fibronectin type III domain
      pfam07714
      Location:615874
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:541610
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      22535722..22747006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335039.1XP_054191014.1  ephrin type-B receptor 2 isoform X2

      UniProtKB/TrEMBL
      Q4LE53
    2. XM_054335040.1XP_054191015.1  ephrin type-B receptor 2 isoform X3

      UniProtKB/TrEMBL
      Q4LE53
    3. XM_054335038.1XP_054191013.1  ephrin type-B receptor 2 isoform X1

      UniProtKB/TrEMBL
      Q4LE53