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    Cct6b chaperonin containing TCP1 subunit 6B [ Mus musculus (house mouse) ]

    Gene ID: 12467, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cct6bprovided by MGI
    Official Full Name
    chaperonin containing TCP1 subunit 6Bprovided by MGI
    Primary source
    MGI:MGI:1329013
    See related
    Ensembl:ENSMUSG00000020698 AllianceGenome:MGI:1329013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cctz-2; CCTzeta-2; CCT-zeta-2; TCP-1-zeta-2
    Summary
    Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in protein folding. Part of chaperonin-containing T-complex. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human CCT6B (chaperonin containing TCP1 subunit 6B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 23.6) See more
    Orthologs
    human all
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    Genomic context

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    See Cct6b in Genome Data Viewer
    Location:
    11 C; 11 50.18 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82603938..82655154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82713112..82764388, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24612 Neighboring gene STARR-seq mESC enhancer starr_30176 Neighboring gene predicted gene 11426 Neighboring gene GTP binding protein 3 pseudogene Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7027 Neighboring gene zinc finger protein 830 Neighboring gene predicted gene 11423

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. T-complex protein 1 subunit zeta-2 (CCT6B) deficiency induces murine teratospermia. Yang P, et al. PeerJ, 2021. PMID 34141486, Free PMC Article
    2. Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B. Cazin C, et al. Cells, 2021 Dec 30. PMID 35011680, Free PMC Article
    3. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. Kubota H, et al. FEBS Lett, 1997 Jan 27. PMID 9013858
    4. Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits. Kubota H, et al. Eur J Biochem, 1999 Jun. PMID 10336634
    5. Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome. Le Bras S, et al. Gene, 2002 Aug 21. PMID 12383505

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chaperonin-containing T-complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 1 subunit zeta-2
    Names
    chaperonin containing Tcp1, subunit 6b (zeta)
    chaperonin subunit 6b (zeta)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291242.2 → NP_001278171.1  T-complex protein 1 subunit zeta-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5'-terminal exon, which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL645594
      Consensus CDS
      CCDS70265.1
      UniProtKB/TrEMBL
      B1AT05, Q8BVT1
      Related
      ENSMUSP00000098288.5, ENSMUST00000100722.5
      Conserved Domains (2) summary
      cd03342
      Location:7 → 487
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02347
      Location:7 → 491
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    2. NM_001430877.1 → NP_001417806.1  T-complex protein 1 subunit zeta-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645594
      UniProtKB/TrEMBL
      Q8BVT1

    3. NM_001430878.1 → NP_001417807.1  T-complex protein 1 subunit zeta-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645594
      UniProtKB/TrEMBL
      Q8BVT1

    4. NM_009839.4 → NP_033969.2  T-complex protein 1 subunit zeta-2 isoform 1

      See identical proteins and their annotated locations for NP_033969.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL645594
      Consensus CDS
      CCDS25145.1
      UniProtKB/Swiss-Prot
      Q61390, Q9R1U2
      UniProtKB/TrEMBL
      Q497N0, Q8BVT1
      Related
      ENSMUSP00000021040.4, ENSMUST00000021040.10
      Conserved Domains (2) summary
      cd03342
      Location:8 → 526
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02347
      Location:3 → 530
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    RNA

    1. NR_191046.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645594

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82603938..82655154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245508.2 → XP_030101368.1  T-complex protein 1 subunit zeta-2 isoform X3

      Conserved Domains (1) summary
      cd03342
      Location:7 → 416
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...

    2. XM_006532108.3 → XP_006532171.1  T-complex protein 1 subunit zeta-2 isoform X2

      Conserved Domains (1) summary
      cd03342
      Location:8 → 455
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...

    3. XM_006532107.4 → XP_006532170.1  T-complex protein 1 subunit zeta-2 isoform X1

      UniProtKB/TrEMBL
      Q8BVT1
      Conserved Domains (1) summary
      TIGR02347
      Location:1 → 464
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    RNA

    1. XR_001779867.3 RNA Sequence

    2. XR_879512.3 RNA Sequence

    3. XR_003949272.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61390.4 GenPept UniProtKB/Swiss-Prot:Q61390

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