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    ams2 GATA-type transcription factor Ams2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539242, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ams2
    Official Full Name
    GATA-type transcription factor Ams2
    Primary source
    PomBase:SPCC290.04
    Locus tag
    SPOM_SPCC290.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPCC4F11.01
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    Genomic context

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    See ams2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (2001159..2004364)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene nucleoporin Nup186 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein phosphatase PP2C catalytic subunit Ptc1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two distinct pathways responsible for the loading of CENP-A to centromeres in the fission yeast cell cycle. Takahashi K, et al. Philos Trans R Soc Lond B Biol Sci, 2005 Mar 29. PMID 15897182, Free PMC Article
    2. Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast. Lim KK, et al. Sci Rep, 2015 Sep 15. PMID 26369364, Free PMC Article
    3. Transcription factors mediate condensin recruitment and global chromosomal organization in fission yeast. Kim KD, et al. Nat Genet, 2016 Oct. PMID 27548313, Free PMC Article
    4. Myb-domain protein Teb1 controls histone levels and centromere assembly in fission yeast. Valente LP, et al. EMBO J, 2013 Feb 6. PMID 23314747, Free PMC Article
    5. Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription. Takayama Y, et al. Sci Rep, 2016 Nov 30. PMID 27901072, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that Ams2 destruction via both the APC/C and the SCF ubiquitin ligases underlies the coordination of histone expression and DNA replication
      Title: Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast.
    2. propose that Hsk1 plays a vital role during post S phase in genome stability via SCF(Pof3)-mediated degradation of Ams2, thereby maintaining centromere integrity
      Title: Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables centromeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric core domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    GATA-type transcription factor Ams2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2001159..2004364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023391.3 → NP_588400.2  GATA-type transcription factor Ams2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588400.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7Z1, Q9URT4
      Conserved Domains (1) summary
      cd00202
      Location:351 → 406
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    Nucleotide Protein
    Heading Accession and Version

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