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    num1 dynein-anchoring factor Num1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540712, updated on 18-Sep-2024

    Summary

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    Official Symbol
    num1
    Official Full Name
    dynein-anchoring factor Num1
    Primary source
    PomBase:SPBC216.02
    Locus tag
    SPOM_SPBC216.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mcp5; mug21
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    Genomic context

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    See num1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (898056..901363)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene serine/threonine protein phosphatase PP4 regulatory subunit 3 Psy2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene peptide-methionine (R)-S-oxide reductase Mxr2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance. Chacko LA, et al. J Cell Biol, 2019 Nov 4. PMID 31582398, Free PMC Article
    2. Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast. Saito TT, et al. J Cell Biol, 2006 Apr 10. PMID 16585273, Free PMC Article
    3. Fission yeast myosin I facilitates PI(4,5)P(2)-mediated anchoring of cytoplasmic dynein to the cortex. Thankachan JM, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28292899, Free PMC Article
    4. Fission yeast Num1p is a cortical factor anchoring dynein and is essential for the horse-tail nuclear movement during meiotic prophase. Yamashita A, et al. Genetics, 2006 Jul. PMID 16624923, Free PMC Article
    5. A conserved mechanism for mitochondria-dependent dynein anchoring. Kraft LM, et al. Mol Biol Cell, 2019 Mar 1. PMID 30649994, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance
      Title: Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance.
    2. Dynein anchoring is established by cooperation of transient assembly of dynactin and function of Num1 at the cell cortex.
      Title: Dynactin and Num1 cooperate to establish the cortical anchoring of cytoplasmic dynein in S. pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cardiolipin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to cytoskeletal protein-membrane anchor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables cytoskeletal protein-membrane anchor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytoskeletal protein-membrane anchor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mitochondrion-plasma membrane adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of mitochondrion localization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in horsetail-astral microtubule organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in horsetail-astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of protein location in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane, cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein-anchoring factor Num1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      898056..901363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021261.3 → NP_595354.1  dynein-anchoring factor Num1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595354.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Y7J9
      Conserved Domains (1) summary
      pfam12814
      Location:840 → 959
      Mcp5_PH; Meiotic cell cortex C-terminal pleckstrin homology
    Nucleotide Protein
    Heading Accession and Version

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