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    msh2 DNA mismatch repair protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540695, updated on 18-Sep-2024

    Summary

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    Official Symbol
    msh2
    Official Full Name
    DNA mismatch repair protein
    Primary source
    PomBase:SPBC19G7.01c
    Locus tag
    SPOM_SPBC19G7.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mut3; SPBC24C6.12c; swi8
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    Genomic context

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    See msh2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (2343653..2347723, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit VIb related protein Neighboring gene endocytosis protein Dip1 Neighboring gene G10 protein Neighboring gene ncRNA Neighboring gene 4-amino-4-deoxychorismate lyase Neighboring gene 40S ribosomal protein eS30

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization. Rudolph C, et al. Mol Cell Biol, 1999 Jan. PMID 9858548, Free PMC Article
    2. Requirement for Msh6, but not for Swi4 (Msh3), in Msh2-dependent repair of base-base mismatches and mononucleotide loops in Schizosaccharomyces pombe. Tornier C, et al. Genetics, 2001 May. PMID 11333218, Free PMC Article
    3. The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved. Miyabe I, et al. PLoS Genet, 2011 Dec. PMID 22144917, Free PMC Article
    4. Mutagenesis of the HMGB (high-mobility group B) protein Cmb1 (cytosine-mismatch binding 1) of Schizosaccharomyces pombe: effects on recognition of DNA mismatches and damage. Kunz C, et al. Biochem J, 2003 Jun 1. PMID 12617726, Free PMC Article
    5. Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Rudolph C, et al. Curr Genet, 1998 Dec. PMID 9871115

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Y-form DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-strand/single-strand DNA junction binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to guanine/thymine mispair binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to heteroduplex DNA loop binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mismatched DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single base insertion or deletion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in gene conversion at mating-type locus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of DNA repeat elements IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MutSalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA mismatch repair protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2343653..2347723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356256.2 → NP_001342761.1  DNA mismatch repair protein [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42950, O74773
      Conserved Domains (1) summary
      COG0249
      Location:9 → 976
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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