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    ste20 target of rapamycin complex 2 subunit ste20 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539845, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ste20
    Official Full Name
    target of rapamycin complex 2 subunit ste20
    Primary source
    PomBase:SPBC12C2.02c
    Locus tag
    SPOM_SPBC12C2.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ste16
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    Genomic context

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    See ste20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2475879..2480462)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene methionine synthase reductase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene PAK-like kinase Nak1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast. Morigasaki S, et al. J Cell Sci, 2019 Oct 10. PMID 31477575
    2. Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Hatano T, et al. Cell Cycle, 2015. PMID 25590601, Free PMC Article
    3. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Ikeda K, et al. Cell Cycle, 2008 Feb 1. PMID 18235227, Free PMC Article
    4. Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Matsuo T, et al. Mol Cell Biol, 2007 Apr. PMID 17261596, Free PMC Article
    5. Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. Tatebe H, et al. Elife, 2017 Mar 7. PMID 28264193, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    target of rapamycin complex 2 subunit ste20

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2475879..2480462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021929.3 → NP_596021.1  target of rapamycin complex 2 subunit ste20 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596021.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09743
      Conserved Domains (5) summary
      pfam14663
      Location:926 → 1025
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:237 → 612
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14666
      Location:697 → 917
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:1095 → 1163
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
      cl00087
      Location:34 → 108
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    Nucleotide Protein
    Heading Accession and Version

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