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    fim1 fimbrin [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539765, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fim1
    Official Full Name
    fimbrin
    Primary source
    PomBase:SPBC1778.06c
    Locus tag
    SPOM_SPBC1778.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See fim1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3106242..3108808, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene guanyl-nucleotide exchange factor Lam2 Neighboring gene Spo4-Spo6 kinase complex regulatory subunit Spo6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene carnosine N-methyltransferase Neighboring gene ncRNA Neighboring gene ARP2/3 actin-organizing complex subunit Arc21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily conserved sites in yeast tropomyosin function in cell polarity, transport and contractile ring formation. Cranz-Mileva S, et al. Biol Open, 2015 Jul 17. PMID 26187949, Free PMC Article
    2. Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast. Christensen JR, et al. Elife, 2019 Jun 10. PMID 31180322, Free PMC Article
    3. Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring. Takaine M, et al. EMBO J, 2009 Oct 21. PMID 19713940, Free PMC Article
    4. Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks. Christensen JR, et al. Elife, 2017 Mar 10. PMID 28282023, Free PMC Article
    5. Fimbrin and tropomyosin competition regulates endocytosis and cytokinesis kinetics in fission yeast. Skau CT, et al. Curr Biol, 2010 Aug 24. PMID 20705466, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data sugest that fimbrin (Fim1) competes with alpha-actinin (Ain1) for association with F-actin, and prevents tropomyosin Cdc8's association with actin patches.
      Title: Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast.
    2. Furthermore, Cdc8, Fim1, and Adf1 all compete for association with F-actin by different mechanisms, and their cooperative association with actin filaments affects their ability to compete.
      Title: Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
    3. Fim1 has diverse roles as both a filament "gatekeeper" and as a filament cross-linker.
      Title: Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cortical patch organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin contractile ring organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in formin-nucleated actin cable organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT is_active_in formin-nucleated actin cable IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, distal actin filament layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fimbrin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3106242..3108808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022211.3 → NP_596289.1  fimbrin [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596289.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59945
      Conserved Domains (4) summary
      smart00033
      Location:389 → 493
      CH; Calponin homology domain
      COG5069
      Location:1 → 614
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00014
      Location:113 → 233
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00307
      Location:513 → 611
      CH; Calponin homology (CH) domain
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials