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    sea3 SEA complex subunit Sea3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541877, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sea3
    Official Full Name
    SEA complex subunit Sea3
    Primary source
    PomBase:SPAC11E3.05
    Locus tag
    SPOM_SPAC11E3.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sea3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5288248..5292558)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene microtubule-site clamp monopolin complex subunit Csm1/Pcs1 Neighboring gene ncRNA Neighboring gene ubiquitin-conjugating enzyme Ubc13 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-binding transcription factor, MADS-box Map1 Neighboring gene V-type ATPase V1 subunit E Neighboring gene Smc5-6 complex non-SMC subunit Nse6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase. Fukuda T, et al. Elife, 2021 Feb 3. PMID 33534698, Free PMC Article
    2. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. Chia KH, et al. Elife, 2017 Dec 4. PMID 29199950, Free PMC Article
    3. Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin. Dong W, et al. Sci Rep, 2020 Apr 8. PMID 32269268, Free PMC Article
    4. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISM
    Inferred from Sequence Model
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GATOR1 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of GATOR2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of Seh1-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Seh1-associated complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in vacuolar membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SEA complex subunit Sea3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5288248..5292558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020361.3 → NP_594930.1  SEA complex subunit Sea3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594930.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13686
      Conserved Domains (5) summary
      smart00591
      Location:672 → 777
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      COG2319
      Location:105 → 488
      WD40; WD40 repeat [General function prediction only]
      pfam17120
      Location:1259 → 1318
      Zn_ribbon_17; Zinc-ribbon, C4HC2 type
      sd00039
      Location:278 → 319
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:288 → 541
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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