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    Cdk15 cyclin-dependent kinase 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk15provided by RGD
    Official Full Name
    cyclin-dependent kinase 15provided by RGD
    Primary source
    RGD:1306205
    See related
    EnsemblRapid:ENSRNOG00000022899 AllianceGenome:RGD:1306205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fzd7
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Orthologous to human CDK15 (cyclin dependent kinase 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 6.1), Testes (RPKM 3.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk15 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (68205759..68299218)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60710787..60803638)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66059765..66153729)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene alsin Rho guanine nucleotide exchange factor ALS2 Neighboring gene uncharacterized LOC134480372 Neighboring gene ribosomal protein S2, pseudogene 15 Neighboring gene uncharacterized LOC134480290 Neighboring gene uncharacterized LOC134480373

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34. Park MH, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24866247
    2. The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. Brynczka C, et al. Differentiation, 2008 Sep. PMID 18177422, Free PMC Article
    3. Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. Li CM, et al. Am J Pathol, 2002 Jun. PMID 12057921, Free PMC Article
    4. Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Yu H, et al. Development, 2012 Dec 1. PMID 23095888, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 15
    Names
    frizzled family receptor 7
    XP_038940773.1
    XP_038940775.1
    XP_038940776.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431239.1 → NP_001418168.1  cyclin-dependent kinase 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R7D0

    2. NM_001431240.1 → NP_001418169.1  cyclin-dependent kinase 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R7D0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      68205759..68299218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084848.2 → XP_038940776.1  cyclin-dependent kinase 15 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:104 → 285
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039084845.2 → XP_038940773.1  cyclin-dependent kinase 15 isoform X1

      Related
      ENSRNOP00000065356.4, ENSRNOT00000071819.5
      Conserved Domains (1) summary
      cd07870
      Location:104 → 389
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    3. XM_039084847.2 → XP_038940775.1  cyclin-dependent kinase 15 isoform X1

      Conserved Domains (1) summary
      cd07870
      Location:104 → 389
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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