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    Smox spermine oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308652, updated on 9-Dec-2024

    Summary

    Official Symbol
    Smoxprovided by RGD
    Official Full Name
    spermine oxidaseprovided by RGD
    Primary source
    RGD:1306049
    See related
    EnsemblRapid:ENSRNOG00000021255 AllianceGenome:RGD:1306049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables polyamine oxidase activity. Involved in spermine catabolic process. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human SMOX (spermine oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 116.3), Thymus (RPKM 74.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Smox in Genome Data Viewer
    Location:
    3q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (139184793..139220174)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118731814..118767242)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (124068796..124103726)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoproteins A2/B1 pseudogene Neighboring gene ribosomal protein S3a, pseudogene 4 Neighboring gene uncharacterized LOC134486446 Neighboring gene adrenoceptor alpha 1D Neighboring gene endogenous retrovirus group V member 2, envelope

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables polyamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polyamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in polyamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within spermine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    spermine oxidase
    NP_001128326.1
    XP_006235125.1
    XP_006235126.1
    XP_006235127.1
    XP_038960731.1
    XP_038960732.1
    XP_038960734.1
    XP_038960735.1
    XP_038960736.1
    XP_038960737.1
    XP_063139606.1
    XP_063139607.1
    XP_063139608.1
    XP_063139609.1
    XP_063139610.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134854.2NP_001128326.1  spermine oxidase isoform b

      See identical proteins and their annotated locations for NP_001128326.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZYI4, A6HQE1, B1WBU6, F7F9S8
      Conserved Domains (2) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase
      pfam13450
      Location:4588
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    2. NM_001431592.1NP_001418521.1  spermine oxidase isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JY83, A0A8I5ZYI4
    3. NM_001431593.1NP_001418522.1  spermine oxidase isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZYI4, A6HQE1, B1WBU6, F7F9S8
    4. NM_001431594.1NP_001418523.1  spermine oxidase isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZYI4, A6HQE1, B1WBU6, F7F9S8
    5. NM_001431595.1NP_001418524.1  spermine oxidase isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZYI4
    6. NM_001431596.1NP_001418525.1  spermine oxidase isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZYI4, B1H229
    7. NM_001431597.1NP_001418526.1  spermine oxidase isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZYI4
    8. NM_001431598.1NP_001418527.1  spermine oxidase isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZYI4
    9. NM_001431599.1NP_001418528.1  spermine oxidase isoform g

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    10. NM_001431600.1NP_001418529.1  spermine oxidase isoform h

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HQE3
    11. NM_001431601.1NP_001418530.1  spermine oxidase isoform h

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HQE3
    12. NM_001431602.1NP_001418531.1  spermine oxidase isoform i

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HQE3
    13. NM_001431603.1NP_001418532.1  spermine oxidase isoform i

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HQE3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      139184793..139220174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235065.5XP_006235127.1  spermine oxidase isoform X5

      Related
      ENSRNOP00000100139.1, ENSRNOT00000128745.1
      Conserved Domains (2) summary
      PLN02568
      Location:50517
      PLN02568; polyamine oxidase
      pfam13450
      Location:4588
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    2. XM_039104809.2XP_038960737.1  spermine oxidase isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZYI4
      Conserved Domains (1) summary
      PLN02568
      Location:50459
      PLN02568; polyamine oxidase
    3. XM_006235063.5XP_006235125.1  spermine oxidase isoform X1

      Related
      ENSRNOP00000070554.2, ENSRNOT00000079264.3
      Conserved Domains (2) summary
      PLN02568
      Location:50578
      PLN02568; polyamine oxidase
      pfam13450
      Location:4588
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    4. XM_006235064.5XP_006235126.1  spermine oxidase isoform X2

      Related
      ENSRNOP00000028876.2, ENSRNOT00000028876.5
      Conserved Domains (2) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase
      pfam13450
      Location:4588
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    5. XM_039104808.2XP_038960736.1  spermine oxidase isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZYI4
      Conserved Domains (1) summary
      PLN02568
      Location:50445
      PLN02568; polyamine oxidase
    6. XM_039104806.2XP_038960734.1  spermine oxidase isoform X4

      Conserved Domains (1) summary
      PLN02568
      Location:127514
      PLN02568; polyamine oxidase
    7. XM_039104807.2XP_038960735.1  spermine oxidase isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZYI4
      Conserved Domains (1) summary
      PLN02568
      Location:50445
      PLN02568; polyamine oxidase
    8. XM_063283536.1XP_063139606.1  spermine oxidase isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY83, A0A8I5ZYI4
    9. XM_063283537.1XP_063139607.1  spermine oxidase isoform X2

    10. XM_063283539.1XP_063139609.1  spermine oxidase isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZYI4
    11. XM_039104804.2XP_038960732.1  spermine oxidase isoform X4

      Conserved Domains (1) summary
      PLN02568
      Location:127514
      PLN02568; polyamine oxidase
    12. XM_063283540.1XP_063139610.1  spermine oxidase isoform X9

    13. XM_063283538.1XP_063139608.1  spermine oxidase isoform X4

    14. XM_039104803.2XP_038960731.1  spermine oxidase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZYI4
      Conserved Domains (1) summary
      PLN02568
      Location:34537
      PLN02568; polyamine oxidase