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    Fmr1 fragile X messenger ribonucleoprotein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24948, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fmr1provided by RGD
    Official Full Name
    fragile X messenger ribonucleoprotein 1provided by RGD
    Primary source
    RGD:2623
    See related
    EnsemblRapid:ENSRNOG00000057464 AllianceGenome:RGD:2623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FMRP
    Summary
    Enables RNA binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and negative regulation of transport. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendrite; and distal axon. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic cytosol. Used to study autism spectrum disorder and fragile X syndrome. Biomarker of alcohol use disorder; myoclonic-atonic epilepsy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (fragile X messenger ribonucleoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 201.0), Lung (RPKM 137.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fmr1 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (152284857..152322686)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (147240239..147278057)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (154684924..154722369, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ADRM1 26S proteasome ubiquitin receptor, pseudogene 2 Neighboring gene heterogeneous nuclear ribonucleoprotein H1, pseudogene 3 Neighboring gene FMR1 neighbor Neighboring gene RIKEN cDNA 1700020N15 gene like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-quadruplex RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-quadruplex RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables N6-methyladenosine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N6-methyladenosine-containing RNA reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA strand annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA strand annealing activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 5'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(G) binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(U) RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables siRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to L-glutamate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to potassium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in evoked excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in excitatory chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inhibitory chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular glutamate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membraneless organelle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membraneless organelle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within_positive_effect miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect miRNA-mediated post-transcriptional gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in modulation by host of viral RNA genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of long-term synaptic depression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of miRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of miRNA-mediated gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovarian follicle development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular transport of viral material ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of miRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA-mediated gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuronal action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of translation at postsynapse, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of translation at presynapse, modulating synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of translation at presynapse, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation at presynapse, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cocaine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to gonadotropin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to interleukin-17 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in skeletal muscle organ development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SMN complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromocenter ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromocenter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium tip IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in growth cone filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membraneless organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in proximal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spine apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fragile X messenger ribonucleoprotein 1
    Names
    FMRP translational regulator 1
    protein FMR-1
    synaptic functional regulator FMR1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431548.1NP_001418477.1  fragile X messenger ribonucleoprotein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P70568, Q80WE1
      UniProtKB/TrEMBL
      A6KQ98
    2. NM_001431611.1NP_001418540.1  fragile X messenger ribonucleoprotein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    3. NM_001431612.1NP_001418541.1  fragile X messenger ribonucleoprotein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2JZV8
    4. NM_001431613.1NP_001418542.1  fragile X messenger ribonucleoprotein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    5. NM_001431614.1NP_001418543.1  fragile X messenger ribonucleoprotein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    6. NM_052804.3NP_434691.1  fragile X messenger ribonucleoprotein 1 isoform 2

      See identical proteins and their annotated locations for NP_434691.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6KQ97
      Conserved Domains (5) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      cd00105
      Location:286325
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam05641
      Location:63120
      Agenet; Agenet domain
      pfam12235
      Location:398538
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:516581
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      152284857..152322686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229532.5XP_006229594.1  fragile X messenger ribonucleoprotein 1 isoform X3

      Related
      ENSRNOP00000074033.2, ENSRNOT00000087893.3
      Conserved Domains (5) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      cd00105
      Location:286325
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam05641
      Location:63120
      Agenet; Agenet domain
      pfam12235
      Location:398550
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:528593
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    2. XM_006229530.5XP_006229592.1  fragile X messenger ribonucleoprotein 1 isoform X1

      Related
      ENSRNOP00000071204.1, ENSRNOT00000089743.3
      Conserved Domains (6) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      cd00105
      Location:286325
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam05641
      Location:63120
      Agenet; Agenet domain
      pfam12235
      Location:419571
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:549614
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      pfam16624
      Location:314392
      zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger
    3. XM_006229531.5XP_006229593.1  fragile X messenger ribonucleoprotein 1 isoform X2

      Conserved Domains (6) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      pfam00013
      Location:283323
      KH_1; KH domain
      pfam05641
      Location:63120
      Agenet; Agenet domain
      pfam12235
      Location:419559
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:537602
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      pfam16624
      Location:314392
      zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger
    4. XM_017601917.3XP_017457406.1  fragile X messenger ribonucleoprotein 1 isoform X4

    5. XM_017601918.3XP_017457407.1  fragile X messenger ribonucleoprotein 1 isoform X5

      Related
      ENSRNOP00000099925.1, ENSRNOT00000173683.1
    6. XM_039099491.2XP_038955419.1  fragile X messenger ribonucleoprotein 1 isoform X7

      Conserved Domains (6) summary
      pfam12235
      Location:419512
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      cd20471
      Location:155
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd22506
      Location:123199
      KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22509
      Location:218280
      KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cl00098
      Location:281423
      KH-I; K homology (KH) RNA-binding domain, type I
    7. XM_063279814.1XP_063135884.1  fragile X messenger ribonucleoprotein 1 isoform X6

    8. XM_063279816.1XP_063135886.1  fragile X messenger ribonucleoprotein 1 isoform X6

    9. XM_063279815.1XP_063135885.1  fragile X messenger ribonucleoprotein 1 isoform X6