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    Tpbg trophoblast glycoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83684, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tpbgprovided by RGD
    Official Full Name
    trophoblast glycoproteinprovided by RGD
    Primary source
    RGD:621453
    See related
    EnsemblRapid:ENSRNOG00000010694 AllianceGenome:RGD:621453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    5T4; WAIF1
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including dendrite arborization; olfactory learning; and positive regulation of intracellular signal transduction. Predicted to be located in axon terminus; dendrite; and endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human TPBG (trophoblast glycoprotein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 45.8), Lung (RPKM 45.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpbg in Genome Data Viewer
    Location:
    8q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (95673993..95677364)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (86793953..86797324)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (93491761..93495132)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094219 Neighboring gene ribosomal protein L7 like 3 Neighboring gene uncharacterized LOC134480084 Neighboring gene ubiquitin protein ligase E3D Neighboring gene stathmin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen. Shaw DM, et al. Biochem J, 2002 Apr 1. PMID 11903056, Free PMC Article
    2. Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Barrow KM, et al. Dev Dyn, 2005 Aug. PMID 15977177
    3. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
    4. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93332

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendrite arborization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mesenchymal cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within olfactory learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trophoblast glycoprotein
    Names
    5T4 oncofetal trophoblast glycoprotein
    5T4 oncotrophoblast glycoprotein
    wnt-activated inhibitory factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431631.1 → NP_001418560.1  trophoblast glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5PQV5, Q9QYD9
      UniProtKB/TrEMBL
      A6I1T6

    2. NM_031807.3 → NP_113995.2  trophoblast glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5PQV5, Q9QYD9
      UniProtKB/TrEMBL
      A6I1T6
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:91 → 154
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      95673993..95677364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243499.5 → XP_006243561.1  trophoblast glycoprotein isoform X1

      Related
      ENSRNOP00000099969.1, ENSRNOT00000153056.1
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:91 → 154
      LRR_8; Leucine rich repeat

    2. XM_017595935.3 → XP_017451424.1  trophoblast glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q5PQV5, Q9QYD9
      UniProtKB/TrEMBL
      A6I1T6
      Related
      ENSRNOP00000100654.1, ENSRNOT00000139740.1
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:91 → 154
      LRR_8; Leucine rich repeat

    3. XM_008766457.4 → XP_008764679.1  trophoblast glycoprotein isoform X1

      See identical proteins and their annotated locations for XP_008764679.1

      UniProtKB/Swiss-Prot
      Q5PQV5, Q9QYD9
      UniProtKB/TrEMBL
      A6I1T6
      Related
      ENSRNOP00000101915.1, ENSRNOT00000130631.1
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:91 → 154
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQV5.1 GenPept UniProtKB/Swiss-Prot:Q5PQV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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