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    Chst10 carbohydrate sulfotransferase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140568, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chst10provided by RGD
    Official Full Name
    carbohydrate sulfotransferase 10provided by RGD
    Primary source
    RGD:621216
    See related
    EnsemblRapid:ENSRNOG00000012815 AllianceGenome:RGD:621216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    sul-T; HNK1ST; Hnk-1st; raHNK-1ST
    Summary
    Enables HNK-1 sulfotransferase activity. Predicted to be involved in androgen metabolic process; estrogen metabolic process; and proteoglycan biosynthetic process. Predicted to act upstream of or within learning and long-term memory. Located in Golgi membrane. Orthologous to human CHST10 (carbohydrate sulfotransferase 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 96.6), Spleen (RPKM 19.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chst10 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (48588575..48618487, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (41092805..41122737, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (45528928..45559365, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene LON peptidase N-terminal domain and ring finger 2 Neighboring gene uncharacterized LOC134480286 Neighboring gene uncharacterized LOC134480359 Neighboring gene U6 spliceosomal RNA Neighboring gene neuromedin S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential expression of two glucuronyltransferases synthesizing HNK-1 carbohydrate epitope in the sublineages of the rat myogenic progenitors. Nagase T, et al. Mech Dev, 2000 Nov. PMID 11044619
    2. Expression cloning of a cDNA encoding a sulfotransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope. Bakker H, et al. J Biol Chem, 1997 Nov 21. PMID 9368071
    3. HNK-1 sulfotransferase-dependent sulfation regulating laminin-binding glycans occurs in the post-phosphoryl moiety on α-dystroglycan. Nakagawa N, et al. Glycobiology, 2013 Sep. PMID 23723439
    4. Physical and functional association of glucuronyltransferases and sulfotransferase involved in HNK-1 biosynthesis. Kizuka Y, et al. J Biol Chem, 2006 May 12. PMID 16543228
    5. Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory. Senn C, et al. Mol Cell Neurosci, 2002 Aug. PMID 12213450

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The function of glucuronyltransfease is relevant to the efficient sequential biosynthesis of the HNK-1 carbohydrate.
      Title: Physical and functional association of glucuronyltransferases and sulfotransferase involved in HNK-1 biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables HNK-1 sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-term memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 10
    Names
    HNK-1 sulfotransferase
    NP_536322.1
    XP_006244792.1
    XP_038938897.1
    XP_063122666.1
    XP_063122667.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431860.1 → NP_001418789.1  carbohydrate sulfotransferase 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O54702
      UniProtKB/TrEMBL
      A6INK4

    2. NM_001431861.1 → NP_001418790.1  carbohydrate sulfotransferase 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O54702
      UniProtKB/TrEMBL
      A6INK4

    3. NM_001431862.1 → NP_001418791.1  carbohydrate sulfotransferase 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O54702
      UniProtKB/TrEMBL
      A6INK4

    4. NM_001431863.1 → NP_001418792.1  carbohydrate sulfotransferase 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O54702
      UniProtKB/TrEMBL
      A6INK4

    5. NM_001431864.1 → NP_001418793.1  carbohydrate sulfotransferase 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O54702
      UniProtKB/TrEMBL
      A6INK4

    6. NM_080397.3 → NP_536322.1  carbohydrate sulfotransferase 10

      See identical proteins and their annotated locations for NP_536322.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O54702
      UniProtKB/TrEMBL
      A0A0G2K5A9, A6INK4
      Related
      ENSRNOP00000017714.7, ENSRNOT00000017714.6
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      48588575..48618487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244730.5 → XP_006244792.1  carbohydrate sulfotransferase 10 isoform X1

      See identical proteins and their annotated locations for XP_006244792.1

      UniProtKB/TrEMBL
      A0A0G2K5A9, A0A8L2Q8P2, A6INK3
      Related
      ENSRNOP00000073358.3, ENSRNOT00000087866.3
      Conserved Domains (1) summary
      pfam03567
      Location:134 → 366
      Sulfotransfer_2; Sulfotransferase family

    2. XM_063266597.1 → XP_063122667.1  carbohydrate sulfotransferase 10 isoform X2

    3. XM_063266596.1 → XP_063122666.1  carbohydrate sulfotransferase 10 isoform X2

    4. XM_039082969.1 → XP_038938897.1  carbohydrate sulfotransferase 10 isoform X3

      Conserved Domains (1) summary
      pfam03567
      Location:48 → 280
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54702.1 GenPept UniProtKB/Swiss-Prot:O54702

    Gene LinkOut

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