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    Adamts17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamts17provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif, 17provided by RGD
    Primary source
    RGD:1308783
    See related
    EnsemblRapid:ENSRNOG00000037080 AllianceGenome:RGD:1308783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 65.0), Kidney (RPKM 15.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamts17 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (129856062..130178430)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (120445800..120768204)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (127802872..128126764)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lines homolog 1 Neighboring gene ceramide synthase 3 Neighboring gene heat shock cognate 71 kDa protein-like Neighboring gene uncharacterized LOC120097339 Neighboring gene uncharacterized LOC120097340 Neighboring gene uncharacterized LOC134483668

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 17
    Names
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432137.1 → NP_001419066.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZWR9, D4ABB3

    2. NM_001432138.1 → NP_001419067.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    3. NM_001432139.1 → NP_001419068.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      129856062..130178430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094338.2 → XP_038950266.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X2

      Conserved Domains (7) summary
      smart00209
      Location:544 → 596
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:230 → 447
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:698 → 808
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:35 → 179
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:464 → 531
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:834 → 886
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00292
      Location:168 → 244
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

    2. XM_218753.11 → XP_218753.6  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X1

      Related
      ENSRNOP00000052730.4, ENSRNOT00000055877.5
      Conserved Domains (8) summary
      smart00209
      Location:544 → 596
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:230 → 447
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam00090
      Location:893 → 946
      TSP_1; Thrombospondin type 1 domain
      pfam01421
      Location:230 → 447
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:61 → 179
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:698 → 808
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1080 → 1106
      PLAC; PLAC (protease and lacunin) domain
      cl00292
      Location:168 → 244
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    Nucleotide Protein Strain
    Heading Accession and Version

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