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    PRKCB protein kinase C beta [ Bos taurus (domestic cattle) ]

    Gene ID: 282325, updated on 4-Oct-2024

    Summary

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    Official Symbol
    PRKCBprovided by VGNC
    Official Full Name
    protein kinase C betaprovided by VGNC
    Primary source
    VGNC:VGNC:33328
    See related
    BGD:BT10706; Ensembl:ENSBTAG00000020921
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PRKCB1
    Orthologs
    human mouse all
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    Genomic context

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    See PRKCB in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (21505317..21880937)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC107131818 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 3 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene RB binding protein 6, ubiquitin ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nishizuka Y. Nature, 1988 Aug 25. PMID 3045562
    2. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Coussens L, et al. Science, 1986 Aug 22. PMID 3755548
    3. Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. Whalen SG, et al. J Biol Chem, 1996 May 17. PMID 8662663
    4. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Park K, et al. Mol Cell Biol, 2013 Aug. PMID 23775122, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study identified the serine phosphorylation (p-Ser) sites induced by PKC-Beta activation or AGT, which inhibits insulin-induced p-Tyr sites on IRS2 and its signals in endothelial cells.
      Title: Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C beta type
    Names
    PKC-B
    PKC-beta
    protein kinase C, beta 1 polypeptide
    NP_777012.1
    XP_005224747.1
    XP_015315798.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174587.1 → NP_777012.1  protein kinase C beta type

      See identical proteins and their annotated locations for NP_777012.1

      Status: PROVISIONAL

      Source sequence(s)
      M13974
      UniProtKB/TrEMBL
      A0A3Q1MGP0
      Related
      ENSBTAP00000070362.2, ENSBTAT00000070516.2
      Conserved Domains (4) summary
      cd04026
      Location:159 → 289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:342 → 600
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05616
      Location:341 → 663
      STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
      pfam00130
      Location:102 → 152
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21505317..21880937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005224690.5 → XP_005224747.1  protein kinase C beta type isoform X1

      See identical proteins and their annotated locations for XP_005224747.1

      UniProtKB/Swiss-Prot
      A5D7N0, P05126
      UniProtKB/TrEMBL
      A0A3Q1MGP0
      Related
      ENSBTAP00000065659.1, ENSBTAT00000084339.2
      Conserved Domains (4) summary
      cd04026
      Location:159 → 289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd20833
      Location:35 → 92
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:102 → 155
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cl21453
      Location:341 → 664
      PKc_like; Protein Kinases, catalytic domain

    2. XM_015460312.3 → XP_015315798.1  protein kinase C beta type isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MGP0, A0AAF6Z8W8
      Related
      ENSBTAP00000027870.5, ENSBTAT00000027870.6
      Conserved Domains (4) summary
      cd04026
      Location:110 → 240
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:293 → 551
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05616
      Location:292 → 614
      STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
      pfam00130
      Location:53 → 103
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05126.4 GenPept UniProtKB/Swiss-Prot:P05126

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