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    SLC22A10 solute carrier family 22 member 10 [ Homo sapiens (human) ]

    Gene ID: 387775, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLC22A10provided by HGNC
    Official Full Name
    solute carrier family 22 member 10provided by HGNC
    Primary source
    HGNC:HGNC:18057
    See related
    Ensembl:ENSG00000184999 MIM:607580; AllianceGenome:HGNC:18057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OAT5; hOAT5
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver (RPKM 17.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC22A10 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63289903..63363144)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63279174..63301052)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63057375..63079255)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 25 Neighboring gene uncharacterized LOC105369334 Neighboring gene cyclin D2 pseudogene 1 Neighboring gene solute carrier family 22 member 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63202489-63203041 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63203042-63203593 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63215327-63216263 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63216264-63217199 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63219920-63220481 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:63220482-63221042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63227984-63228595 Neighboring gene zinc finger protein 91 pseudogene Neighboring gene phospholipase A and acyltransferase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 10
    Names
    organic anion transporter 5
    solute carrier family 22 (organic anion/cation transporter), member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039752.4NP_001034841.3  solute carrier family 22 member 10

      See identical proteins and their annotated locations for NP_001034841.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AB075876, AP001880, BK001421, BX091233, CB162810, DR003989
      Consensus CDS
      CCDS41661.1
      UniProtKB/Swiss-Prot
      Q63ZE4, Q68CJ0
      Related
      ENSP00000327569.6, ENST00000332793.11
      Conserved Domains (2) summary
      cd06174
      Location:143516
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11526
      2A0119; cation transport protein

    RNA

    1. NR_134874.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' end and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB075876, AK298430, AP001880, CB162810

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63289903..63363144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426920.1XP_047282876.1  solute carrier family 22 member 10 isoform X1

    2. XM_047426924.1XP_047282880.1  solute carrier family 22 member 10 isoform X6

      UniProtKB/TrEMBL
      E9PMM0
    3. XM_047426921.1XP_047282877.1  solute carrier family 22 member 10 isoform X3

    4. XM_017017699.2XP_016873188.1  solute carrier family 22 member 10 isoform X2

    5. XM_047426922.1XP_047282878.1  solute carrier family 22 member 10 isoform X4

      UniProtKB/TrEMBL
      E9PMM0
      Related
      ENSP00000433048.1, ENST00000533483.5
    6. XM_047426925.1XP_047282881.1  solute carrier family 22 member 10 isoform X7

    7. XM_047426923.1XP_047282879.1  solute carrier family 22 member 10 isoform X5

      UniProtKB/TrEMBL
      E9PMM0

    RNA

    1. XR_007062480.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63279174..63301052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)