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    Ackr2 atypical chemokine receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140473, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ackr2provided by RGD
    Official Full Name
    atypical chemokine receptor 2provided by RGD
    Primary source
    RGD:620323
    See related
    EnsemblRapid:ENSRNOG00000019472 AllianceGenome:RGD:620323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    D6; Ccbp2
    Summary
    Predicted to enable C-C chemokine binding activity; C-C chemokine receptor activity; and scavenger receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within signal transduction. Predicted to be located in several cellular components, including actin filament; cytosol; and nucleus. Predicted to be active in external side of plasma membrane. Orthologous to human ACKR2 (atypical chemokine receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 26.4), Liver (RPKM 26.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ackr2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130438703..130451106)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121559563..121573633)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130526521..130543566)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene hedgehog acyltransferase-like Neighboring gene coiled-coil domain containing 13 Neighboring gene HIG1 hypoxia inducible domain family, member 1A Neighboring gene cytochrome P450 family 8 subfamily B member 1 Neighboring gene poly(rC) binding protein 2 like 1 Neighboring gene KRAB box domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression of a novel rat CC-chemokine receptor (rCCR10rR) that binds MCP-1 and MIP-1beta with high affinity. Bonini JA, et al. DNA Cell Biol, 1997 Sep. PMID 9324304
    2. Chemokines: a new classification system and their role in immunity. Zlotnik A, et al. Immunity, 2000 Feb. PMID 10714678
    3. Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. Bonini JA, et al. DNA Cell Biol, 1997 Oct. PMID 9364936
    4. β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Borroni EM, et al. Sci Signal, 2013 Apr 30. PMID 23633677
    5. Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. Nibbs RJ, et al. J Biol Chem, 1997 May 9. PMID 9139699

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105345

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scavenger receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    atypical chemokine receptor 2
    Names
    C-C chemokine receptor D6
    CC-chemokine-binding receptor JAB61
    CCR10-related receptor
    chemokine-binding protein 2
    chemokine-binding protein D6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433059.1 → NP_001419988.1  atypical chemokine receptor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6G8C2, A6I464, Q5U1W0

    2. NM_078621.3 → NP_511176.2  atypical chemokine receptor 2

      See identical proteins and their annotated locations for NP_511176.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O09027
      UniProtKB/TrEMBL
      A0A8I6G8C2, A6I464, Q5U1W0
      Conserved Domains (1) summary
      cd15188
      Location:46 → 323
      7tmA_ACKR2_D6; atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      130438703..130451106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080719.2 → XP_038936647.1  atypical chemokine receptor 2 isoform X1

      Related
      ENSRNOP00000026343.1, ENSRNOT00000026343.6
      Conserved Domains (1) summary
      cd15188
      Location:46 → 323
      7tmA_ACKR2_D6; atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_039080721.2 → XP_038936649.1  atypical chemokine receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      O09027
      UniProtKB/TrEMBL
      A0A8I6G8C2, A6I464, Q5U1W0
      Related
      ENSRNOP00000110589.1, ENSRNOT00000169098.1
      Conserved Domains (1) summary
      cd15188
      Location:46 → 323
      7tmA_ACKR2_D6; atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_039080718.2 → XP_038936646.1  atypical chemokine receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      O09027
      UniProtKB/TrEMBL
      A0A8I6G8C2, A6I464, Q5U1W0
      Related
      ENSRNOP00000111612.1, ENSRNOT00000145003.1
      Conserved Domains (1) summary
      cd15188
      Location:46 → 323
      7tmA_ACKR2_D6; atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09027.1 GenPept UniProtKB/Swiss-Prot:O09027

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