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    Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naalad2provided by RGD
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase 2provided by RGD
    Primary source
    RGD:1305872
    See related
    EnsemblRapid:ENSRNOG00000005955 AllianceGenome:RGD:1305872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-formylglutamate deformylase activity and carboxypeptidase activity. Predicted to be involved in carboxylic acid catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Orthologous to human NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 36.7), Lung (RPKM 20.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Naalad2 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (23682499..23756066, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (15406119..15479714, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (17453198..17525906, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3 alpha, pseudogene 2 Neighboring gene cysteine and histidine rich domain containing 1 Neighboring gene UBTF like 6, pseudogene1 Neighboring gene upstream binding transcription factor like 1 Neighboring gene methyl-CpG binding domain protein 3-like 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cloning and characterization of a second brain enzyme with NAAG peptidase activity. Bzdega T, et al. J Neurochem, 2004 May. PMID 15086519
    2. Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3. Collard F, et al. J Biol Chem, 2011 Nov 4. PMID 21908619, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-formylglutamate deformylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylated-alpha-linked acidic dipeptidase 2
    NP_001100272.1
    XP_006242630.1
    XP_017451014.1
    XP_038936914.1
    XP_038936915.1
    XP_038936917.1
    XP_038936918.1
    XP_038936920.1
    XP_038936921.1
    XP_063121114.1
    XP_063121115.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106802.2 → NP_001100272.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 1

      See identical proteins and their annotated locations for NP_001100272.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNE9, D4A2Y7
      Related
      ENSRNOP00000007855.5, ENSRNOT00000007855.8
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:86 → 143
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. NM_001433038.1 → NP_001419967.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNE9, D4A2Y7

    3. NM_001433047.1 → NP_001419976.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNF0

    4. NM_001433048.1 → NP_001419977.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    5. NM_001433049.1 → NP_001419978.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      23682499..23756066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080987.2 → XP_038936915.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A6JNE9, D4A2Y7
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:86 → 143
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. XM_039080986.2 → XP_038936914.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:86 → 143
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    3. XM_006242568.5 → XP_006242630.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

      See identical proteins and their annotated locations for XP_006242630.1

      Conserved Domains (4) summary
      cd08022
      Location:284 → 531
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:56 → 282
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:568 → 682
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:1 → 50
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    4. XM_039080989.2 → XP_038936917.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A6JNE9, D4A2Y7
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:86 → 143
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    5. XM_017595525.3 → XP_017451014.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A6JNE9, D4A2Y7
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:86 → 143
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    6. XM_063265044.1 → XP_063121114.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

      Related
      ENSRNOP00000072956.2, ENSRNOT00000081679.3

    7. XM_039080990.2 → XP_038936918.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A6JNE9, D4A2Y7
      Conserved Domains (4) summary
      cd02121
      Location:148 → 374
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:382 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:655 → 774
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:86 → 143
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    8. XM_039080993.2 → XP_038936921.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X6

      Conserved Domains (2) summary
      cd08022
      Location:11 → 252
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:284 → 403
      TFR_dimer; Transferrin receptor-like dimerization domain

    9. XM_039080992.2 → XP_038936920.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X5

      Conserved Domains (2) summary
      cd08022
      Location:1 → 277
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:309 → 428
      TFR_dimer; Transferrin receptor-like dimerization domain

    10. XM_063265045.1 → XP_063121115.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

    RNA

    1. XR_005487751.2 RNA Sequence

      Related
      ENSRNOT00000133053.1
    Nucleotide Protein Strain
    Heading Accession and Version

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