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    Ttll7 tubulin tyrosine ligase like 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310982, updated on 9-Dec-2024

    Summary

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    Symbol
    Ttll7provided by RGD
    Full Name
    tubulin tyrosine ligase like 7provided by RGD
    Primary source
    RGD:1566117
    See related
    EnsemblRapid:ENSRNOG00000031997 AllianceGenome:RGD:1566117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566117
    Summary
    Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and tubulin-glutamic acid ligase activity. Predicted to be involved in protein modification process. Predicted to act upstream of or within protein polyglutamylation. Predicted to be located in 9+0 non-motile cilium and ciliary basal body. Orthologous to human TTLL7 (tubulin tyrosine ligase like 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 433.6), Muscle (RPKM 219.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttll7 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (238425786..238549296)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235765786..235889047)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252779741..252854746)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485994 Neighboring gene protein kinase cAMP-activated catalytic subunit beta Neighboring gene uncharacterized LOC108350293 Neighboring gene uncharacterized LOC120100967

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on beta-tubulin through a random sequential pathway. Mukai M, et al. Biochemistry, 2009 Feb 10. PMID 19152315
    2. Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Garnham CP, et al. Cell, 2015 May 21. PMID 25959773, Free PMC Article
    3. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites. Ikegami K, et al. J Biol Chem, 2006 Oct 13. PMID 16901895, Free PMC Article
    4. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    5. Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Ikegami K, et al. Proc Natl Acad Sci U S A, 2007 Feb 27. PMID 17360631, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites
      Title: TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein polyglutamylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyglutamylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin polyglutamylase TTLL7; tubulin tyrosine ligase like 7
    Names
    tubulin polyglutamylase TTLL7-like
    tubulin tyrosine ligase-like family, member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433161.1 → NP_001420090.1  tubulin tyrosine ligase like 7 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4ACG4

    2. NM_001433162.1 → NP_001420091.1  tubulin tyrosine ligase like 7 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4ACG4

    3. NM_001433163.1 → NP_001420092.1  tubulin tyrosine ligase like 7 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4ACG4

    4. NM_001433164.1 → NP_001420093.1  tubulin tyrosine ligase like 7 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4ACG4

    5. NM_001433165.1 → NP_001420094.1  tubulin tyrosine ligase like 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    6. NM_001433166.1 → NP_001420095.1  tubulin tyrosine ligase like 7 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    7. NM_001433167.1 → NP_001420096.1  tubulin tyrosine ligase like 7 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWF3

    8. NM_001433168.1 → NP_001420097.1  tubulin tyrosine ligase like 7 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWF3

    9. NM_001433169.1 → NP_001420098.1  tubulin tyrosine ligase like 7 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWF3

    10. NM_001433170.1 → NP_001420099.1  tubulin tyrosine ligase like 7 isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      238425786..238549296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103873.2 → XP_038959801.1  tubulin polyglutamylase TTLL7 isoform X3

      Related
      ENSRNOP00000052186.6, ENSRNOT00000055318.6
      Conserved Domains (1) summary
      pfam03133
      Location:91 → 376
      TTL; Tubulin-tyrosine ligase family

    2. XM_063282933.1 → XP_063139003.1  tubulin polyglutamylase TTLL7 isoform X9

      UniProtKB/TrEMBL
      D4ACG4

    3. XM_039103880.2 → XP_038959808.1  tubulin polyglutamylase TTLL7 isoform X8

      Conserved Domains (1) summary
      pfam03133
      Location:91 → 376
      TTL; Tubulin-tyrosine ligase family

    4. XM_063282927.1 → XP_063138997.1  tubulin polyglutamylase TTLL7 isoform X4

    5. XM_039103877.2 → XP_038959805.1  tubulin polyglutamylase TTLL7 isoform X3

      Conserved Domains (1) summary
      pfam03133
      Location:91 → 376
      TTL; Tubulin-tyrosine ligase family

    6. XM_063282930.1 → XP_063139000.1  tubulin polyglutamylase TTLL7 isoform X7

    7. XM_063282932.1 → XP_063139002.1  tubulin polyglutamylase TTLL7 isoform X8

    8. XM_063282926.1 → XP_063138996.1  tubulin polyglutamylase TTLL7 isoform X4

      UniProtKB/TrEMBL
      D4ACG4
      Related
      ENSRNOP00000067036.4, ENSRNOT00000075452.5

    9. XM_039103874.2 → XP_038959802.1  tubulin polyglutamylase TTLL7 isoform X3

      Conserved Domains (1) summary
      pfam03133
      Location:91 → 376
      TTL; Tubulin-tyrosine ligase family

    10. XM_063282931.1 → XP_063139001.1  tubulin polyglutamylase TTLL7 isoform X8

    11. XM_063282928.1 → XP_063138998.1  tubulin polyglutamylase TTLL7 isoform X5

    12. XM_063282929.1 → XP_063138999.1  tubulin polyglutamylase TTLL7 isoform X6

    13. XM_063282925.1 → XP_063138995.1  tubulin polyglutamylase TTLL7 isoform X2

      UniProtKB/TrEMBL
      D4ACG4

    14. XM_039103876.2 → XP_038959804.1  tubulin polyglutamylase TTLL7 isoform X3

      UniProtKB/TrEMBL
      D4ACG4
      Conserved Domains (1) summary
      pfam03133
      Location:91 → 376
      TTL; Tubulin-tyrosine ligase family

    15. XM_039103875.2 → XP_038959803.1  tubulin polyglutamylase TTLL7 isoform X3

      UniProtKB/TrEMBL
      D4ACG4
      Conserved Domains (1) summary
      pfam03133
      Location:91 → 376
      TTL; Tubulin-tyrosine ligase family

    16. XM_063282924.1 → XP_063138994.1  tubulin polyglutamylase TTLL7 isoform X1

      UniProtKB/TrEMBL
      D4ACG4
    Nucleotide Protein Strain
    Heading Accession and Version

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