Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacna2d2provided by RGD
Official Full Name: calcium voltage-gated channel auxiliary subunit alpha2delta 2provided by RGD
Primary source: RGD:631360
See related: EnsemblRapid:ENSRNOG00000015835 AllianceGenome:RGD:631360
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables voltage-gated calcium channel activity. Involved in calcium ion transport. Predicted to be part of voltage-gated calcium channel complex. Predicted to be active in GABA-ergic synapse and presynaptic active zone membrane. Orthologous to human CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 46.7), Heart (RPKM 40.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (116950860..117082159)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108072208..108203516)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116154661..116285643)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There was no difference in the mRNA expression of alpha2delta-2 (Cacna2d2) between the BRL group and CHF control group (0.264 +/- 0.005 vs. 0.243 +/- 0.017, P>0.05), which was also higher than in the normal control group (0.137 +/- 0.013, P<0.01).
Title: Effect of β3-adrenergic receptor on atrial L-type Ca(2+) current in rats with chronic heart failure.
The level of the alpha1C (Cacna1c) (Cav1.2) protein was decreased (approximately 0.5-fold) and that of alpha2 delta-1 (Cacna2d1) was increased (approximately 2-fold) in the atrium compared with the ventricle
Title: Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts.
The alpha2delta-2 subunit is also found in brain regions known to be involved in olfaction, somatic motor control, fluid homeostasis, ingestive and defensive behaviors, neuroendocrine functions, and circadian rhythm.
Title: Differential distribution of voltage-gated calcium channel alpha-2 delta (alpha2delta) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular junction development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in organ growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of organ growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of organ growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in rhythmic synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhythmic synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: voltage-dependent calcium channel subunit alpha-2/delta-2

Names: calcium channel, voltage dependent, alpha2/delta subunit 2; calcium channel, voltage-dependent, alpha 2/delta subunit 2; voltage-gated calcium channel subunit alpha-2/delta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433258.1 → NP_001420187.1 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_175592.3 → NP_783182.2 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I2X1

Related

ENSRNOP00000021216.6, ENSRNOT00000021218.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

116950860..117082159

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265241.1 → XP_063121311.1 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1

UniProtKB/TrEMBL

A6I2X1
XM_006243735.4 → XP_006243797.1 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X3

UniProtKB/Swiss-Prot

Q8CFG6

Conserved Domains (4) summary

cd01463
Location:280 → 459

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam02743
Location:488 → 576

Cache_1; Cache domain

pfam08399
Location:144 → 268

VWA_N; VWA N-terminal

pfam08473
Location:583 → 666

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
XM_063265242.1 → XP_063121312.1 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X2
XM_006243736.4 → XP_006243798.1 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X6

UniProtKB/Swiss-Prot

Q8CFG6

Conserved Domains (4) summary

cd01463
Location:280 → 459

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam02743
Location:488 → 576

Cache_1; Cache domain

pfam08399
Location:144 → 268

VWA_N; VWA N-terminal

pfam08473
Location:583 → 667

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
XM_063265243.1 → XP_063121313.1 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X4
XM_006243737.4 → XP_006243799.1 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X7

Conserved Domains (4) summary

cd01463
Location:280 → 459

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam02743
Location:488 → 576

Cache_1; Cache domain

pfam08399
Location:144 → 268

VWA_N; VWA N-terminal

pfam08473
Location:583 → 667

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
XM_063265244.1 → XP_063121314.1 voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X5

Related

ENSRNOP00000071469.3, ENSRNOT00000081242.3