Jmy junction mediating and regulatory protein, p53 cofactor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jmyprovided by RGD
Official Full Name: junction mediating and regulatory protein, p53 cofactorprovided by RGD
Primary source: RGD:1585601
See related: EnsemblRapid:ENSRNOG00000050343 AllianceGenome:RGD:1585601
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Arp2/3 complex binding activity; microtubule binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including actin nucleation; actin polymerization-dependent cell motility; and intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in autophagosome membrane; cell leading edge; and cytoplasmic vesicle. Predicted to be active in cytoplasm and nucleus. Orthologous to human JMY (junction mediating and regulatory protein, p53 cofactor). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Uterus (RPKM 143.6), Kidney (RPKM 123.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (26401047..26465959, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (24662104..24730955, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (23026506..23097702, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Jmy is upregulated during myelination and is required for the assembly of actin filaments and protrusion formation during oligodendrocyte differentiation. Quantitative morphodynamics analysis of live oligodendrocytes showed that differentiation is driven by a stereotypical actin network-dependent "cellular shaping" program.
Title: Jmy regulates oligodendrocyte differentiation via modulation of actin cytoskeleton dynamics.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' actin filament nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' actin filament nucleation	ISO Inferred from Sequence Orthology more info
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization-dependent cell motility	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: junction mediating and regulatory protein, p53 cofactor; junction-mediating and -regulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433238.1 → NP_001420167.1 junction mediating and regulatory protein, p53 cofactor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

M0R8J3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

26401047..26465959 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103451.2 → XP_038959379.1 junction-mediating and -regulatory protein isoform X1

Related

ENSRNOP00000065789.3, ENSRNOT00000075286.5

Conserved Domains (4) summary

PHA03307
Location:51 → 213

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:473 → 676

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15871
Location:216 → 569

JMY; Junction-mediating and -regulatory protein

pfam15920
Location:6 → 54

WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated
XM_039103452.2 → XP_038959380.1 junction-mediating and -regulatory protein isoform X2

UniProtKB/TrEMBL

A0A8I6A624

Related

ENSRNOP00000088902.1, ENSRNOT00000108057.2

Conserved Domains (3) summary

PHA03307
Location:51 → 213

PHA03307; transcriptional regulator ICP4; Provisional

pfam15871
Location:216 → 569

JMY; Junction-mediating and -regulatory protein

pfam15920
Location:6 → 54

WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated