tnnt3b troponin T type 3b (skeletal, fast) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnnt3bprovided by ZNC
Official Full Name: troponin T type 3b (skeletal, fast)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030520-2
See related: Ensembl:ENSDARG00000068457 AllianceGenome:ZFIN:ZDB-GENE-030520-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: b44; cb44; sb:cb44
Summary: Predicted to enable tropomyosin binding activity; troponin C binding activity; and troponin I binding activity. Acts upstream of or within sarcomere organization. Predicted to be part of troponin complex. Is expressed in musculature system and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (39444845..39460363)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (39173856..39189346)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complete loss of troponin T3a, T3b and T2c activities leads to loss of sarcomere structure.
Title: Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle.
Tnnt1, Tnnt2, and Tnnt3b were conserved in the central tropomyosin- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 and Tnnt2, but not Tnnt3b.
Title: Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin C binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: troponin T type 3b (skeletal, fast)

Names: troponin T3b, skeletal, fast

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110416.2 → NP_001103886.1 troponin T type 3b (skeletal, fast) isoform 1

See identical proteins and their annotated locations for NP_001103886.1

Status: VALIDATED

Source sequence(s)

BX842701

UniProtKB/TrEMBL

A0A8M1NGK1, A8WGA6

Related

ENSDARP00000121128.1, ENSDART00000142946.4

Conserved Domains (2) summary

pfam00992
Location:93 → 230

Troponin; Troponin

cl01454
Location:96 → 137

PhnG; Phosphonate metabolizm protein PhnG
NM_001423828.1 → NP_001410757.1 troponin T type 3b (skeletal, fast) isoform 3

Status: VALIDATED

Source sequence(s)

BX842701

Related

ENSDARP00000142801.1, ENSDART00000173754.2
NM_001423829.1 → NP_001410758.1 troponin T type 3b (skeletal, fast) isoform 4

Status: VALIDATED

Source sequence(s)

BX842701

Related

ENSDARP00000142633.1, ENSDART00000173748.2
NM_001423830.1 → NP_001410759.1 troponin T type 3b (skeletal, fast) isoform 5

Status: VALIDATED

Source sequence(s)

BX842701

Related

ENSDARP00000117932.2, ENSDART00000145457.4
NM_001423831.1 → NP_001410760.1 troponin T type 3b (skeletal, fast) isoform 6

Status: VALIDATED

Source sequence(s)

BX842701

Related

ENSDARP00000093830.4, ENSDART00000103056.6
NM_181653.3 → NP_857636.1 troponin T type 3b (skeletal, fast) isoform 2

See identical proteins and their annotated locations for NP_857636.1

Status: VALIDATED

Source sequence(s)

BX842701

UniProtKB/TrEMBL

F6NJY9, Q78BH6, Q7ZZW4

Related

ENSDARP00000115079.1, ENSDART00000141750.3

Conserved Domains (2) summary

pfam00992
Location:41 → 178

Troponin; Troponin

cl01454
Location:44 → 85

PhnG; Phosphonate metabolizm protein PhnG

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

39444845..39460363

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068222103.1 → XP_068078204.1 troponin T type 3b (skeletal, fast) isoform X1
XM_068222105.1 → XP_068078206.1 troponin T type 3b (skeletal, fast) isoform X2
XM_068222106.1 → XP_068078207.1 troponin T type 3b (skeletal, fast) isoform X3

Related

ENSDARP00000142762.1, ENSDART00000173554.2
XM_068222107.1 → XP_068078208.1 troponin T type 3b (skeletal, fast) isoform X4
XM_068222108.1 → XP_068078209.1 troponin T type 3b (skeletal, fast) isoform X5