sc scute [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: scprovided by FlyBase
Official Full Name: scuteprovided by FlyBase
Primary source: FLYBASE:FBgn0004170
Locus tag: Dmel_CG3827
See related: AllianceGenome:FB:FBgn0004170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AS-C T4; AS-C T4sc; ascT4; bHLHc28; CG3827; Dmel\CG3827; DROACS2; EG:198A6.1; Hw; l(1)1Ba; Sc; sc/T4; scalpha; Scute; scute/sisterlessB; SC_DA; sis b; sis-b; sisb; sisB; T4; T4 AS-C
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule tip cell differentiation; chaeta morphogenesis; and nervous system development. Part of transcription regulator complex. Is expressed in several structures, including adult mesothoracic sensillum; gut section; neurogenic region; procephalic segment; and somatic precursor cell. Orthologous to several human genes including ASCL1 (achaete-scute family bHLH transcription factor 1); ASCL2 (achaete-scute family bHLH transcription factor 2); and ASCL3 (achaete-scute family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1A8-1A8; 1-0 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (396060..397497)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (290093..291530)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here we show that, in intestinal stem cell lineages in adult Drosophila, in which the Delta-Notch-signalling-guided progenitor cell differentiation into enterocytes is the default mode, the specification of enteroendocrine cells (EEs) is initiated by transient Scute activation in a process driven by transcriptional self-stimulation combined with a negative feedback regulation between Scute and Notch targets.
Title: Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.
Results show that both Esg and Sc bind to a common promoter region of pros. Moreover, antagonistic activity between Esg and Sc controls the expression status of Pros in stem cells, thereby, specifying whether stem cells remain undifferentiated or commit to enteroendocrine cell differentiation.
Title: Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells.
Data show that bHLHb22 protein daughterless (Da) binding alters the turnover parameters of bHLHc28 protein scute (Sc).
Title: bHLH proteins involved in Drosophila neurogenesis are mutually regulated at the level of stability.
Proneural proteins Achaete and Scute associate with nuclear actin to promote formation of external sensory organs.
Title: Proneural proteins Achaete and Scute associate with nuclear actin to promote formation of external sensory organs.
quantified the relationship between achaete-scute complex (ASC) polymorphisms and bristle number phenotypes in several new population samples
Title: How repeatable are associations between polymorphisms in achaete-scute and bristle number variation in Drosophila?
interchanging E(Ato) and E(Sc) sites within enhancers almost abolishes enhancer activity
Title: The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites.
achaete, but not scute, is dispensable for development of the peripheral nervous system of Drosophila.
Title: achaete, but not scute, is dispensable for the peripheral nervous system of Drosophila.
overexpression of chn enhances expression and the formation of extra sensory organs
Title: Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila.
the Sc C-terminal domain is required for E(spl) recruitment in an enhancer context-dependent fashion, suggesting that in some enhancers alternative interaction surfaces can be used to recruit E(spl) proteins
Title: Role of the Sc C terminus in transcriptional activation and E(spl) repressor recruitment.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule tip cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in enteroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in neuroblast fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex determination	TAS Traceable Author Statement more info	PubMed
involved_in sex determination, establishment of X:A ratio	NAS Non-traceable Author Statement more info	PubMed
involved_in ventral cord development	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed