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    eIF3b eukaryotic translation initiation factor 3 subunit b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF3bprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 3 subunit bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034237
    Locus tag
    Dmel_CG4878
    See related
    AllianceGenome:FB:FBgn0034237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4878; CG4878; Dmel\CG4878; eIF3; eIF3 S9; eIF3-s9; eIF3-S9; eIF3B; EIF3B; SN2-6
    Summary
    Predicted to enable mRNA binding activity. Predicted to contribute to translation initiation factor activity. Involved in follicle cell of egg chamber development. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human EIF3B (eukaryotic translation initiation factor 3 subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See eIF3b in Genome Data Viewer
    Location:
    54C3-54C3; 2-83 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17536213..17539142)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13423718..13426647)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Anaphase Promoting Complex subunit 10 Neighboring gene patronin Neighboring gene uncharacterized protein Neighboring gene Coiled-coil and C2 domain containing 2A Neighboring gene uncharacterized protein Neighboring gene cyclophilin-33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells. Song Z, et al. Nucleic Acids Res, 2022 Nov 11. PMID 36330957, Free PMC Article
    2. Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. Farny NG, et al. RNA, 2009 Oct. PMID 19661161, Free PMC Article
    3. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Goodman LD, et al. Acta Neuropathol Commun, 2019 Apr 25. PMID 31023341, Free PMC Article
    4. The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation. Andersen DS, et al. J Biol Chem, 2007 May 18. PMID 17392269
    5. The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm. Ramat A, et al. Cell Res, 2020 May. PMID 32132673, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables translation initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit b
    Names
    CG4878-PA
    CG4878-PB
    eIF3-S9
    eIF3b-PA
    eIF3b-PB
    suppressor of NA9 2-6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17536213..17539142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137384.3 → NP_611228.1  eukaryotic translation initiation factor 3 subunit b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611228.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0PUW0, Q0E940, Q8MR84
      UniProtKB/TrEMBL
      E2QCG7
      Related
      FBpp0086097
      Conserved Domains (4) summary
      COG5354
      Location:194 → 690
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      cd12278
      Location:56 → 137
      RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
      sd00039
      Location:216 → 248
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:216 → 352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_166239.4 → NP_725691.1  eukaryotic translation initiation factor 3 subunit b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0PUW0, Q0E940, Q8MR84
      UniProtKB/TrEMBL
      E2QCG7
      Related
      FBpp0086098
      Conserved Domains (4) summary
      COG5354
      Location:194 → 690
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      cd12278
      Location:56 → 137
      RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
      sd00039
      Location:216 → 248
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:216 → 352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCG7 E2QCG7
    Q0E940.1 Q0E940

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