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    Pdp1 PAR-domain protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45588, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdp1provided by FlyBase
    Official Full Name
    PAR-domain protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0016694
    Locus tag
    Dmel_CG17888
    See related
    AllianceGenome:FB:FBgn0016694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.206; CG17888; DM1; DM32; Dmel\CG17888; mel_pdp1; pdp; PDP; Pdp-1; PDP-1epsilon; pdp1; PDP1; Pdp1 epsilon; PDP1 epsilon; Pdp1&e;gr; Pdp1e; pdp1epsilon; Pdp1epsilon; PDP1epsilon
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in circadian rhythm; positive regulation of DNA-templated transcription; and regulation of lipid metabolic process. Located in nucleus. Is expressed in several structures, including adult pacemaker neurons; gut section; midgut primordium; pharyngeal muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including HLF (HLF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pdp1 in Genome Data Viewer
    Location:
    66A14-66A17; 3-21 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7811458..7867369, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7804558..7860469, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Clock Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 4E5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila PAR domain protein 1 (Pdp1) gene encodes multiple differentially expressed mRNAs and proteins through the use of multiple enhancers and promoters. Reddy KL, et al. Dev Biol, 2000 Aug 15. PMID 10926776
    2. Reduction of Cellular Lipid Content by a Knockdown of Drosophila PDP1 γ and Mammalian Hepatic Leukemia Factor. Dzitoyeva S, et al. J Lipids, 2013. PMID 24062952, Free PMC Article
    3. Cryptochrome-dependent and -independent circadian entrainment circuits in Drosophila. Yoshii T, et al. J Neurosci, 2015 Apr 15. PMID 25878285, Free PMC Article
    4. Co-operation between enhancers modulates quantitative expression from the Drosophila Paramyosin/miniparamyosin gene in different muscle types. Marco-Ferreres R, et al. Mech Dev, 2005 May. PMID 15817225
    5. The Drosophila Par domain protein I gene, Pdp1, is a regulator of larval growth, mitosis and endoreplication. Reddy KL, et al. Dev Biol, 2006 Jan 1. PMID 16313897

    See all (228) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Candidate proteins with strong PRBH signals associated with the cell cortex but were displaced into the cytoplasm by aPKC. These findings demonstrate a potentially general mechanism for exclusion of proteins from the Par cortical domain in polarized cell
      Title: Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.
    2. Our data uncover a pathway from the positive arm of the circadian clock through Pdp1 to detoxification effector genes, demonstrating a conserved role of the circadian system in modulating xenobiotic toxicity.
      Title: Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway.
    3. Data show that takeout levels are low in flies with reduced Pdp1epsilon and high in flies with increased amounts of Pdp1epsilon.
      Title: The circadian output gene takeout is regulated by Pdp1epsilon.
    4. Transgenic expression of PDP1 epsilon in clock neurons of Pdp1 epsilon mutants can restore rhythmic circadian behavior.
      Title: An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator.
    5. PDP1-target genes may be involved in the formation of neural connection between the pacemaker cells and their targets for maintaining the rhythmicity of adult locomotor activity under free-running condition.
      Title: Targeted inhibition of Pdp1epsilon abolishes the circadian behavior of Drosophila melanogaster.
    6. Clk, vri, and Pdp-1 have roles in controlling Drosophila circadian oscillations, as shown in a simulation
      Title: Simulation of Drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK.
    7. Pdp1 has a critical role in coordinating growth and DNA replication.
      Title: The Drosophila Par domain protein I gene, Pdp1, is a regulator of larval growth, mitosis and endoreplication.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PAR-domain protein 1
    Names
    CG17888-PB
    CG17888-PC
    CG17888-PD
    CG17888-PF
    CG17888-PG
    CG17888-PI
    CG17888-PJ
    CG17888-PK
    CG17888-PL
    CG17888-PM
    CG17888-PN
    CG17888-PO
    CG17888-PP
    PAR domain protein 1epsilon
    PAR-DOMAIN-PROTEIN 1
    PAR-Domain protein 1
    PAR-protein domain1
    Par domain protein 1
    Pdp1-PB
    Pdp1-PC
    Pdp1-PD
    Pdp1-PF
    Pdp1-PG
    Pdp1-PI
    Pdp1-PJ
    Pdp1-PK
    Pdp1-PL
    Pdp1-PM
    Pdp1-PN
    Pdp1-PO
    Pdp1-PP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7811458..7867369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080093.5 → NP_524832.3  PAR-domain protein 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524832.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KKI2, Q86P99
      Conserved Domains (1) summary
      cd14695
      Location:203 → 262
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    2. NM_001300044.1 → NP_001286973.1  PAR-domain protein 1, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KKI2, Q86P99
      Conserved Domains (1) summary
      cd14695
      Location:203 → 262
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    3. NM_168233.3 → NP_729297.1  PAR-domain protein 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729297.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL48, Q9TVQ4
      Related
      FBpp0076490
      Conserved Domains (1) summary
      cd14695
      Location:183 → 242
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    4. NM_001274618.1 → NP_001261547.1  PAR-domain protein 1, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBV3, Q86P99
      Conserved Domains (1) summary
      cd14695
      Location:197 → 256
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    5. NM_168234.3 → NP_729298.2  PAR-domain protein 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729298.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24217, Q86P99, Q9TVF8
      Conserved Domains (1) summary
      cd14695
      Location:165 → 224
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    6. NM_168235.3 → NP_729299.1  PAR-domain protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729299.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KKI2, Q86P99
      Related
      FBpp0076491
      Conserved Domains (1) summary
      cd14695
      Location:203 → 262
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    7. NM_001274616.1 → NP_001261545.1  PAR-domain protein 1, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261545.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEP3, Q86P99
      Conserved Domains (1) summary
      cd14695
      Location:208 → 267
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    8. NM_001274617.1 → NP_001261546.1  PAR-domain protein 1, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261546.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U8V5, Q86P99
      Conserved Domains (1) summary
      cd14695
      Location:214 → 273
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    9. NM_168236.3 → NP_729300.1  PAR-domain protein 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729300.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P99, Q9TW49
      Related
      FBpp0076492
      Conserved Domains (1) summary
      cd14695
      Location:217 → 276
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    10. NM_168238.3 → NP_729302.2  PAR-domain protein 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729302.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ99
      Conserved Domains (1) summary
      cd14695
      Location:566 → 625
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    11. NM_168237.2 → NP_729301.1  PAR-domain protein 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZT1
      Related
      FBpp0076495
      Conserved Domains (1) summary
      cd14695
      Location:580 → 639
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    12. NM_001274615.1 → NP_001261544.1  PAR-domain protein 1, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEX4
      Conserved Domains (1) summary
      cd14695
      Location:514 → 573
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    13. NM_168239.2 → NP_729303.1  PAR-domain protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729303.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ98
      Related
      FBpp0076497
      Conserved Domains (1) summary
      cd14695
      Location:503 → 562
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBV3 M9PBV3
    M9PEP3 M9PEP3
    M9PEX4 M9PEX4
    Q24217 Q24217
    Q5U8V5 Q5U8V5
    Q7KKI2 Q7KKI2
    Q86P99 Q86P99
    Q8IQ98 Q8IQ98
    Q8IQ99 Q8IQ99
    Q8SZT1 Q8SZT1
    Q9TVQ4 Q9TVQ4
    Q9TVS7 Q9TVS7
    Q9TVY0 Q9TVY0
    Q9TW49 Q9TW49

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