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    Trip4 thyroid hormone receptor interactor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315769, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trip4provided by RGD
    Official Full Name
    thyroid hormone receptor interactor 4provided by RGD
    Primary source
    RGD:1306838
    See related
    EnsemblRapid:ENSRNOG00000016121 AllianceGenome:RGD:1306838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including estrogen receptor signaling pathway; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including centrosome; neuromuscular junction; and nuclear body. Predicted to be part of activating signal cointegrator 1 complex. Predicted to be active in nucleus. Orthologous to human TRIP4 (thyroid hormone receptor interactor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 44.0), Thymus (RPKM 43.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trip4 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75248352..75334802, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66351861..66439679, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71369121..71533281, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693122 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene U6 spliceosomal RNA Neighboring gene PCNA clamp associated factor Neighboring gene casein kinase 1, gamma 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The transcription coactivator ASC-1 is a regulator of skeletal myogenesis, and its deficiency causes a novel form of congenital muscle disease. Davignon L, et al. Hum Mol Genet, 2016 Apr 15. PMID 27008887
    2. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Knierim E, et al. Am J Hum Genet, 2016 Mar 3. PMID 26924529, Free PMC Article
    3. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Kim HJ, et al. Mol Cell Biol, 1999 Sep. PMID 10454579, Free PMC Article
    4. Novel transcription coactivator complex containing activating signal cointegrator 1. Jung DJ, et al. Mol Cell Biol, 2002 Jul. PMID 12077347, Free PMC Article
    5. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Yoo HM, et al. Mol Cell, 2014 Oct 23. PMID 25219498

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188852

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RQC-trigger complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of activating signal cointegrator 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    activating signal cointegrator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134981.2 → NP_001128453.1  activating signal cointegrator 1

      See identical proteins and their annotated locations for NP_001128453.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AG66, B5DEP5, F7FN66
      Related
      ENSRNOP00000021863.4, ENSRNOT00000021863.9
      Conserved Domains (2) summary
      cd06554
      Location:434 → 547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168 → 216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type

    2. NM_001433738.1 → NP_001420667.1  activating signal cointegrator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    3. NM_001433739.1 → NP_001420668.1  activating signal cointegrator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    4. NM_001433740.1 → NP_001420669.1  activating signal cointegrator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    5. NM_001433741.1 → NP_001420670.1  activating signal cointegrator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    6. NM_001433742.1 → NP_001420671.1  activating signal cointegrator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75248352..75334802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766281.4 → XP_008764503.3  activating signal cointegrator 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0P5, A0A8I6A5V7
      Related
      ENSRNOP00000071531.2, ENSRNOT00000085745.3
      Conserved Domains (2) summary
      cd06554
      Location:535 → 648
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:269 → 317
      zf-C2HC5; Putative zinc finger motif, C2HC5-type

    2. XM_039081508.2 → XP_038937436.1  activating signal cointegrator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5V7, A0A8I6AWC1
      Related
      ENSRNOP00000097416.1, ENSRNOT00000094012.2
      Conserved Domains (2) summary
      cd06554
      Location:552 → 665
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:286 → 334
      zf-C2HC5; Putative zinc finger motif, C2HC5-type

    RNA

    1. XR_010053965.1 RNA Sequence

    2. XR_005487825.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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