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    Kremen1 kringle containing transmembrane protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114107, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kremen1provided by RGD
    Official Full Name
    kringle containing transmembrane protein 1provided by RGD
    Primary source
    RGD:620789
    See related
    EnsemblRapid:ENSRNOG00000051487 AllianceGenome:RGD:620789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kremen
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including negative regulation of axon regeneration; negative regulation of canonical Wnt signaling pathway; and negative regulation of ossification. Predicted to be located in neuronal cell body. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Orthologous to human KREMEN1 (kringle containing transmembrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 92.1), Heart (RPKM 58.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kremen1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84295931..84361534, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80081870..80147489, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85441209..85503661, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1 Neighboring gene chromosome 14 C22orf31 homolog Neighboring gene zinc and ring finger 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist Kremen1. Wu D, et al. Front Mol Neurosci, 2013. PMID 24167472, Free PMC Article
    2. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Nakamura T, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267660
    3. Function and biological roles of the Dickkopf family of Wnt modulators. Niehrs C. Oncogene, 2006 Dec 4. PMID 17143291
    4. Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner. Causeret F, et al. Cell Death Differ, 2016 Feb. PMID 26206087, Free PMC Article
    5. Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Ellwanger K, et al. Mol Cell Biol, 2008 Aug. PMID 18505822, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in limb development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle organ development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of axon regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kremen protein 1
    Names
    dickkopf receptor
    kringle domain-containing transmembrane protein 1
    kringle-coding gene marking the eye and the nose
    kringle-containing protein marking the eye and the nose
    XP_038947484.1
    XP_063128872.1
    XP_063128873.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433772.1 → NP_001420701.1  kremen protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    2. NM_053649.2 → NP_446101.2  kremen protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      Related
      ENSRNOP00000085129.1, ENSRNOT00000120167.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84295931..84361534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091556.2 → XP_038947484.1  kremen protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G4R3
      Conserved Domains (3) summary
      cd00041
      Location:214 → 320
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00108
      Location:29 → 114
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      pfam01822
      Location:120 → 200
      WSC; WSC domain

    2. XM_063272802.1 → XP_063128872.1  kremen protein 1 isoform X2

    3. XM_063272803.1 → XP_063128873.1  kremen protein 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924S4.1 GenPept UniProtKB/Swiss-Prot:Q924S4

    Gene LinkOut

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