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    KIF3C kinesin family member 3C [ Homo sapiens (human) ]

    Gene ID: 3797, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KIF3Cprovided by HGNC
    Official Full Name
    kinesin family member 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:6321
    See related
    Ensembl:ENSG00000084731 MIM:602845; AllianceGenome:HGNC:6321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule cytoskeleton; neuronal cell body; and neuronal ribonucleoprotein granule. Predicted to be part of kinesin complex. Predicted to be active in microtubule. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 57.3), adrenal (RPKM 4.3) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF3C in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (25926598..25982497, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (25961945..26017861, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26149467..26205366, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ASXL transcriptional regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15465 Neighboring gene Sharpr-MPRA regulatory region 10168 Neighboring gene prostaglandin E synthase 3 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26083605-26084105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11264 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26202609-26203118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26203119-26203627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:26204137-26204645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:26204646-26205155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11267 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26234163-26234664 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26234665-26235164 Neighboring gene ubiquinol-cytochrome c reductase hinge protein pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26251416-26251944 Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling. Wang C, et al. Cancer Lett, 2015 Nov 1. PMID 26272184
    2. KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway. Gao Y, et al. J Neurooncol, 2020 Feb. PMID 32020481
    3. Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis. Chen J, et al. Int J Oral Sci, 2023 Sep 26. PMID 37752101, Free PMC Article
    4. KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT. Gao Y, et al. Biomed Res Int, 2020. PMID 33150178, Free PMC Article
    5. KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. Sardella M, et al. Genomics, 1998 Feb 1. PMID 9480755

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis.
      Title: Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis.
    2. Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
      Title: Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
    3. KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
      Title: KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
    4. KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
      Title: KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
    5. Results suggest that high expression of KIF3C in breast cancer may be associated with tumor progression and metastasis.
      Title: Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling.
    6. FMRP acts also as a molecular adaptor between RNA granules and the neurospecific kinesin KIF3C.
      Title: The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of kinesin family member 3C (KIF3C) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary tip TAS
    Traceable Author Statement
    more info
    		  
    located_in cilium TAS
    Traceable Author Statement
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF3C
    Names
    KIF3C variant protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002254.8 → NP_002245.4  kinesin-like protein KIF3C

      See identical proteins and their annotated locations for NP_002245.4

      Status: VALIDATED

      Source sequence(s)
      AC013449, AC064847, KF456639
      Consensus CDS
      CCDS1719.1
      UniProtKB/Swiss-Prot
      O14782, O43544, Q4ZG18, Q53SX5, Q562F7
      UniProtKB/TrEMBL
      A2RU78, B7ZM25, Q7Z2W5
      Related
      ENSP00000264712.3, ENST00000264712.8
      Conserved Domains (4) summary
      cd01371
      Location:9 → 365
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
      pfam00225
      Location:16 → 365
      Kinesin; Kinesin motor domain
      cd16269
      Location:538 → 549
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:461 → 569
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      25926598..25982497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264299.4 → XP_005264356.2  kinesin-like protein KIF3C isoform X1

      UniProtKB/TrEMBL
      B7ZM25
      Conserved Domains (4) summary
      cd01371
      Location:9 → 365
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
      pfam00225
      Location:16 → 365
      Kinesin; Kinesin motor domain
      cd16269
      Location:538 → 549
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:461 → 569
      GBP_C; Guanylate-binding protein, C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      25961945..26017861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341956.1 → XP_054197931.1  kinesin-like protein KIF3C isoform X1

      UniProtKB/TrEMBL
      B7ZM25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14782.4 GenPept UniProtKB/Swiss-Prot:O14782

    Gene LinkOut

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