safb scaffold attachment factor B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: safbprovided by ZNC
Official Full Name: scaffold attachment factor Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-698
See related: Ensembl:ENSDARG00000020467 AllianceGenome:ZFIN:ZDB-GENE-030131-698
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55387; wu:fb40a03; wu:fd42g06
Summary: Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in regulation of mRNA processing and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including SAFB (scaffold attachment factor B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (15695746..15704704, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (15669476..15678434, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of mRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: scaffold attachment factor B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214683.1 → NP_999848.1 scaffold attachment factor B1

See identical proteins and their annotated locations for NP_999848.1

Status: PROVISIONAL

Source sequence(s)

BC044153

UniProtKB/TrEMBL

Q803X6

Related

ENSDARP00000005702.8, ENSDART00000017838.10

Conserved Domains (2) summary

smart00513
Location:19 → 53

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12679
Location:384 → 459

RRM_SAFB1_SAFB2; RNA recognition motif in scaffold attachment factor B1 (SAFB1), scaffold attachment factor B2 (SAFB2), and similar proteins