Nmur1 neuromedin U receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmur1provided by MGI
Official Full Name: neuromedin U receptor 1provided by MGI
Primary source: MGI:MGI:1341898
See related: Ensembl:ENSMUSG00000026237 AllianceGenome:MGI:1341898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FM-3; Gpr66; NMU1R; NmU-R; NMU-R1
Summary: Enables neuropeptide receptor activity. Acts upstream of or within neuropeptide signaling pathway. Is active in cilium. Is expressed in brain; esophagus; and male reproductive gland or organ. Orthologous to human NMUR1 (neuromedin U receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 6.3), small intestine adult (RPKM 3.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.94 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (86313964..86317083, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (86386242..86389361, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuromedin U regulates the anti-tumor activity of CD8[+] T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
Title: Neuromedin U regulates the anti-tumor activity of CD8(+) T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.
Title: Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.
Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
Title: Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
Neuromedin U (NMU) regulates osteoblast differentiation and activity.
Title: Neuromedin U (NMU) regulates osteoblast differentiation and activity.
These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis.
Title: Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic β cells.
Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity.
Title: The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
results suggested that NMU increases I(A) via activation of NMUR1 that couples sequentially to the downstream activities of Gbetagamma of the G(o) protein, PKA, and ERK
Title: Neuromedin U type 1 receptor stimulation of A-type K+ current requires the βγ subunits of Go protein, protein kinase A, and extracellular signal-regulated kinase 1/2 (ERK1/2) in sensory neurons.
neuromedin-U receptor 1 inhibits L-type HVGCC via activation of NMUR1 and downstream G(betagamma), PI3K, and a novel PKC epsilon signaling pathway.
Title: Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons.
A study evaluating smooth muscle contraction in NMU1 receptor knockout mouse was used to determine which receptor subtype mediates the contractile responses generated by neuromedin in the mouse.[NMU1 receptor]
Title: Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice.
These data argues against a major role for Nmur1 in mediating the reported inflammatory functions of NmU.
Title: Nmur1-/- mice are not protected from cutaneous inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuromedin U binding	IEA Inferred from Electronic Annotation more info
enables neuromedin U binding	ISO Inferred from Sequence Orthology more info
enables neuromedin U receptor activity	IEA Inferred from Electronic Annotation more info
enables neuromedin U receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: neuromedin-U receptor 1

Names: G protein-coupled receptor 66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001319227.1 → NP_001306156.1 neuromedin-U receptor 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC102609, BC120822

Consensus CDS

CCDS15119.2

UniProtKB/Swiss-Prot

G5E871, O55040, Q0VB23

UniProtKB/TrEMBL

A0A1C7ZMY0

Related

ENSMUSP00000148767.2, ENSMUST00000212058.2

Conserved Domains (2) summary

pfam00001
Location:77 → 357

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:64 → 195

7tm_4; Olfactory receptor
NM_010341.1 → NP_034471.1 neuromedin-U receptor 1 isoform 2

See identical proteins and their annotated locations for NP_034471.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the UTRs and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AF044602

Consensus CDS

CCDS83570.1

UniProtKB/TrEMBL

A0A1C7ZMY0

Related

ENSMUSP00000027440.6, ENSMUST00000027440.7

Conserved Domains (2) summary

pfam00001
Location:54 → 334

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:41 → 172

7tm_4; Olfactory receptor