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    Tmem108 transmembrane protein 108 [ Mus musculus (house mouse) ]

    Gene ID: 81907, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem108provided by MGI
    Official Full Name
    transmembrane protein 108provided by MGI
    Primary source
    MGI:MGI:1932411
    See related
    Ensembl:ENSMUSG00000042757 AllianceGenome:MGI:1932411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130017P16Rik
    Summary
    Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Located in several cellular components, including axon; endosome; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in brain. Orthologous to human TMEM108 (transmembrane protein 108). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 2.3), CNS E18 (RPKM 2.1) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Tmem108 in Genome Data Viewer
    Location:
    9 F1; 9 55.47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103360135..103639099, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (103482936..103761900, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E573 Neighboring gene STARR-seq mESC enhancer starr_25091 Neighboring gene RIKEN cDNA 5830418P13 gene Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:103327280-103327581 Neighboring gene STARR-seq mESC enhancer starr_25093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103334789-103334972 Neighboring gene STARR-positive B cell enhancer ABC_E5098 Neighboring gene STARR-seq mESC enhancer starr_25094 Neighboring gene STARR-seq mESC enhancer starr_25095 Neighboring gene beaded filament structural protein 2, phakinin Neighboring gene predicted gene 16252 Neighboring gene STARR-seq mESC enhancer starr_25098 Neighboring gene RIKEN cDNA 4932413F04 gene Neighboring gene predicted gene, 32743 Neighboring gene predicted gene, 32682 Neighboring gene VISTA enhancer mm303 Neighboring gene STARR-seq mESC enhancer starr_25101 Neighboring gene predicted gene, 46129 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene predicted gene 29154 Neighboring gene predicted gene, 32797

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Clone Names

    • KIAA1690

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to brain-derived neurotrophic factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendrite extension IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neurotrophin TRK receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic density organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in postsynaptic density organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde axonal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in somatodendritic compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane protein 108
    Names
    retrolinkin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359465.1NP_001346394.1  transmembrane protein 108 precursor

      Status: VALIDATED

      Source sequence(s)
      AC128698, AC165256
      Consensus CDS
      CCDS23455.1
      UniProtKB/Swiss-Prot
      Q80WR9, Q8BHE4
      Related
      ENSMUSP00000046021.9, ENSMUST00000049452.15
      Conserved Domains (1) summary
      pfam15759
      Location:63574
      TMEM108; TMEM108 family
    2. NM_178638.4NP_848753.1  transmembrane protein 108 precursor

      See identical proteins and their annotated locations for NP_848753.1

      Status: VALIDATED

      Source sequence(s)
      AC165256, AK052330
      Consensus CDS
      CCDS23455.1
      UniProtKB/Swiss-Prot
      Q80WR9, Q8BHE4
      Related
      ENSMUSP00000140027.2, ENSMUST00000189588.7
      Conserved Domains (1) summary
      pfam15759
      Location:63574
      TMEM108; TMEM108 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      103360135..103639099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511868.4XP_006511931.1  transmembrane protein 108 isoform X2

      See identical proteins and their annotated locations for XP_006511931.1

      UniProtKB/Swiss-Prot
      Q80WR9, Q8BHE4
      Related
      ENSMUSP00000141160.2, ENSMUST00000189066.2
      Conserved Domains (1) summary
      pfam15759
      Location:63574
      TMEM108; TMEM108 family
    2. XM_006511864.4XP_006511927.1  transmembrane protein 108 isoform X1

      See identical proteins and their annotated locations for XP_006511927.1

      Conserved Domains (1) summary
      pfam15759
      Location:94605
      TMEM108; TMEM108 family
    3. XM_006511863.4XP_006511926.1  transmembrane protein 108 isoform X1

      See identical proteins and their annotated locations for XP_006511926.1

      Conserved Domains (1) summary
      pfam15759
      Location:94605
      TMEM108; TMEM108 family
    4. XM_006511865.5XP_006511928.1  transmembrane protein 108 isoform X1

      See identical proteins and their annotated locations for XP_006511928.1

      Conserved Domains (1) summary
      pfam15759
      Location:94605
      TMEM108; TMEM108 family
    5. XM_030244730.2XP_030100590.1  transmembrane protein 108 isoform X1

      Conserved Domains (1) summary
      pfam15759
      Location:94605
      TMEM108; TMEM108 family
    6. XM_006511866.5XP_006511929.1  transmembrane protein 108 isoform X1

      See identical proteins and their annotated locations for XP_006511929.1

      Conserved Domains (1) summary
      pfam15759
      Location:94605
      TMEM108; TMEM108 family
    7. XM_030244731.2XP_030100591.1  transmembrane protein 108 isoform X2

      UniProtKB/Swiss-Prot
      Q80WR9, Q8BHE4
      Conserved Domains (1) summary
      pfam15759
      Location:63574
      TMEM108; TMEM108 family