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    Arpc5l actin related protein 2/3 complex, subunit 5-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296710, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arpc5lprovided by RGD
    Official Full Name
    actin related protein 2/3 complex, subunit 5-likeprovided by RGD
    Primary source
    RGD:1308867
    See related
    EnsemblRapid:ENSRNOG00000014317 AllianceGenome:RGD:1308867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arpc5l1
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Predicted to be part of Arp2/3 protein complex. Predicted to be active in cytoplasm and glutamatergic synapse. Orthologous to human ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 362.8), Muscle (RPKM 332.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arpc5l in Genome Data Viewer
    Location:
    3q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (43169518..43177224)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (22758710..22767520)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (23301455..23309077)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA79 Neighboring gene WD repeat domain 38 Neighboring gene ribosomal protein L35 Neighboring gene golgin A1 Neighboring gene uncharacterized LOC134486089 Neighboring gene suppressor of cancer cell invasion like 1 Neighboring gene suppressor of cancer cell invasion

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
    2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112865

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 2/3 complex subunit 5-like protein
    Names
    ARC16-2
    actin related protein 2/3 complex, subunit 5-like 1
    arp2/3 complex 16 kDa subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037767.2 → NP_001032856.2  actin-related protein 2/3 complex subunit 5-like protein

      See identical proteins and their annotated locations for NP_001032856.2

      Status: VALIDATED

      Source sequence(s)
      BC127445, FM029541
      UniProtKB/Swiss-Prot
      A1L108, Q4KM42
      UniProtKB/TrEMBL
      A0A8L2QA00, A6JEW0
      Related
      ENSRNOP00000019405.8, ENSRNOT00000019405.9
      Conserved Domains (1) summary
      pfam04699
      Location:9 → 151
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      43169518..43177224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104789.2 → XP_038960717.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

      Conserved Domains (1) summary
      pfam04699
      Location:1 → 99
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

    2. XM_063283529.1 → XP_063139599.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

    3. XM_039104791.2 → XP_038960719.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

      Conserved Domains (1) summary
      pfam04699
      Location:1 → 99
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

    4. XM_063283530.1 → XP_063139600.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

    5. XM_063283531.1 → XP_063139601.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

    6. XM_039104793.2 → XP_038960721.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

      Conserved Domains (1) summary
      pfam04699
      Location:1 → 99
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

    7. XM_039104794.2 → XP_038960722.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

      Conserved Domains (1) summary
      pfam04699
      Location:1 → 99
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L108.2 GenPept UniProtKB/Swiss-Prot:A1L108

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