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    Ppp4r3c1 protein phosphatase 4 regulatory subunit 3C1 [ Mus musculus (house mouse) ]

    Gene ID: 245511, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ppp4r3c1provided by MGI
    Official Full Name
    protein phosphatase 4 regulatory subunit 3C1provided by MGI
    Primary source
    MGI:MGI:3588286
    See related
    Ensembl:ENSMUSG00000035387 AllianceGenome:MGI:3588286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smek3p; Ppp4r3c; Ppp4r3cp; 4930415L06Rik
    Summary
    Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response and regulation of double-strand break repair. Predicted to be located in nucleus. Predicted to be part of protein phosphatase 4 complex. Predicted to be active in nucleoplasm. Orthologous to human PPP4R3C (protein phosphatase 4 regulatory subunit 3C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Ppp4r3c1 in Genome Data Viewer
    Location:
    X C1; X 39.95 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (88973703..88976458, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (89930097..89932852, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47523 Neighboring gene splicing factor, arginine/serine-rich 2, interacting protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_47524 Neighboring gene Nanog pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_47525 Neighboring gene STARR-seq mESC enhancer starr_47526 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene hemogen like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC183898, MGC183900

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein PPP4R3C1
    Names
    Smek homolog 3
    protein PPP4R3C
    putative SMEK homolog 3
    serine/threonine-protein phosphatase 4 regulatory subunit 3C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033880.3 → NP_001029052.2  protein PPP4R3C1

      See identical proteins and their annotated locations for NP_001029052.2

      Status: VALIDATED

      Source sequence(s)
      AK132812, AL672285
      Consensus CDS
      CCDS53129.1
      UniProtKB/Swiss-Prot
      A2AG62, Q3V0Y1
      UniProtKB/TrEMBL
      B2RX57
      Related
      ENSMUSP00000085471.3, ENSMUST00000088146.3
      Conserved Domains (2) summary
      pfam04802
      Location:178 → 369
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:17 → 83
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      88973703..88976458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_003621.1: Suppressed sequence

      Description
      NR_003621.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V0Y1.2 GenPept UniProtKB/Swiss-Prot:Q3V0Y1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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