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    slc1a3a solute carrier family 1 member 3a [ Danio rerio (zebrafish) ]

    Gene ID: 323439, updated on 4-Jan-2025

    Summary

    Official Symbol
    slc1a3aprovided by ZNC
    Official Full Name
    solute carrier family 1 member 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2159
    See related
    Ensembl:ENSDARG00000104431 AllianceGenome:ZFIN:ZDB-GENE-030131-2159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slc1a3; zgc:56661; zgc:77768; wu:fb98e05; wu:fd50b05
    Summary
    Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in D-aspartate import across plasma membrane; L-aspartate import across plasma membrane; and L-glutamate import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including glioblast; nervous system; neural tube; radial glial cell; and swim bladder. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See slc1a3a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (8111348..8171653, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (7606710..7667051, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene glial cell derived neurotrophic factor b Neighboring gene NIPBL cohesin loading factor a Neighboring gene LMBR1 domain containing 2a Neighboring gene family with sequence similarity 111.2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity  
    enables glutamate:sodium symporter activity  
    enables neutral L-amino acid transmembrane transporter activity  
    enables symporter activity  
    Process Evidence Code Pubs
    involved_in D-aspartate import across plasma membrane  
    involved_in L-aspartate import across plasma membrane  
    involved_in L-glutamate import across plasma membrane  
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    solute carrier family 1 member 3a
    Names
    EAAT1A
    excitatory amino acid transporter SLC1A3a
    glasta
    solute carrier family 1 (glial high affinity glutamate transporter), member 3
    solute carrier family 1 (glial high affinity glutamate transporter), member 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212640.1 → NP_997805.1  solute carrier family 1 member 3a

      Status: PROVISIONAL

      Source sequence(s)
      BC063233
      UniProtKB/TrEMBL
      A0A0R4INN2, A0A2R8Q100, Q6P4V2
      Related
      ENSDARP00000136026.1, ENSDART00000167643.2
      Conserved Domains (1) summary
      pfam00375
      Location:50 → 490
      SDF; Sodium:dicarboxylate symporter family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      8111348..8171653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301170.3 → XP_009299445.1  solute carrier family 1 member 3a isoform X1

      UniProtKB/TrEMBL
      A0A0R4INN2, A0A2R8Q100, Q6P4V2
      Conserved Domains (1) summary
      pfam00375
      Location:50 → 490
      SDF; Sodium:dicarboxylate symporter family
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