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    Galntl5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 67909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galntl5provided by MGI
    Official Full Name
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5provided by MGI
    Primary source
    MGI:MGI:1915159
    See related
    Ensembl:ENSMUSG00000028938 AllianceGenome:MGI:1915159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Galnt15; 1700021B12Rik
    Summary
    Predicted to enable metal ion binding activity. Involved in spermatid development. Predicted to be located in late endosome membrane. Predicted to be active in Golgi apparatus. Is expressed in submandibular gland and submandibular gland primordium. Orthologous to human GALNTL5 (polypeptide N-acetylgalactosaminyltransferase like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 63.9) See more
    Orthologs
    human all
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    Genomic context

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    See Galntl5 in Genome Data Viewer
    Location:
    5 A3; 5 12.33 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (25386438..25425295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (25181440..25220297)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_12657 Neighboring gene STARR-seq mESC enhancer starr_12659 Neighboring gene predicted gene, 33836 Neighboring gene STARR-seq mESC enhancer starr_12661 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 Neighboring gene lysine (K)-specific methyltransferase 2C Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility. Takasaki N, et al. Proc Natl Acad Sci U S A, 2014 Jan 21. PMID 24398516, Free PMC Article
    2. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutated GALNTL5 has a role in male infertility with impairment of sperm motility
      Title: A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
    galNAc-T15
    polypeptide GalNAc transferase 15
    polypeptide N-acetylgalactosaminyltransferase-like 5
    pp-GaNTase 15
    protein-UDP acetylgalactosaminyltransferase 15
    putative polypeptide N-acetylgalactosaminyltransferase-like protein 5
    NP_080725.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026449.3 → NP_080725.2  inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5

      See identical proteins and their annotated locations for NP_080725.2

      Status: VALIDATED

      Source sequence(s)
      AK005605, AK016415
      Consensus CDS
      CCDS19132.1
      UniProtKB/Swiss-Prot
      A6H655, Q810S4, Q9CW06, Q9D4M9
      UniProtKB/TrEMBL
      D3Z533
      Related
      ENSMUSP00000030778.3, ENSMUST00000030778.9
      Conserved Domains (2) summary
      cd02510
      Location:118 → 414
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam10111
      Location:118 → 380
      Glyco_tranf_2_2; Glycosyltransferase like family 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      25386438..25425295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_389751.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4M9.2 GenPept UniProtKB/Swiss-Prot:Q9D4M9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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